Two new ent-labdane diterpenes, ent-3α,16-dihydroxylabda-8(17),12(E),14-triene (1) and ent-14(S),15-dihydroxylabda-8(17)-12(E)-dien-18-oic acid (2), were isolated from the roots of Euphorbia yinshanica. Their structures were elucidated on the basis of spectroscopic methods including HR-ESI-MS and 1D and 2D NMR. The cytotoxic activities against five tumor cell lines was also evaluated, but there was no significant activity.
Euphorbiaceae Euphorbia yinshanicaent-labdane diterpenes cytotoxic activity
This is a preview of subscription content, log in to check access.
This work was supported by the National Natural Science Foundation of China (NSFC, Grant No. 31500049) and Postdoctoral Science Foundation of China (2014M552077).
J. S. Ma and Y. C. Tseng, Flora of China, Vol. 26, Science Press, Beijing, 1997.Google Scholar
A. Zargari, Medicinal Plants, Tehran University Publication, Tehran, 1993.Google Scholar
A. R. Lal, R. C. Cambie, P. S. Rutledge, and P. D. Woodgate, Phytochemistry, 29, 1925 (1990).CrossRefGoogle Scholar
V. Ravikanth, V. L. Niranjan, P. T. Rao, P. V. Diwan, S. Ramakrishna, and Y. Venkateswarlu, Phytochemistry, 59, 331 (2002).CrossRefPubMedGoogle Scholar
V. U. Ahma, H. Hussain, I. A. Bukhari, J. Hussain, A. R. Jassbi, and A. Dar, Fitoterapia, 76, 230 (2005).CrossRefGoogle Scholar
Z. L. Zhao and R. N. Zhao, Chin. Pharm. J., 27, 269 (1992).Google Scholar
B. Y. Zhang, H. Wang, X. D. Luo, Z. Z. Du, J. W. Shen, H. F. Wu, and X. F. Zhang, Helv. Chim. Acta, 92, 1672 (2012).CrossRefGoogle Scholar
Y. J. Kuo, S. Y. Hwang, M. D. Wu, C. C. Liao, Y. H. Liang, Y. H. Kuo, and H. Ho, Chem. Pharm. Bull., 56, 585 (2008).CrossRefPubMedGoogle Scholar