Two new ent-labdane diterpenes, ent-3α,16-dihydroxylabda-8(17),12(E),14-triene (1) and ent-14(S),15-dihydroxylabda-8(17)-12(E)-dien-18-oic acid (2), were isolated from the roots of Euphorbia yinshanica. Their structures were elucidated on the basis of spectroscopic methods including HR-ESI-MS and 1D and 2D NMR. The cytotoxic activities against five tumor cell lines was also evaluated, but there was no significant activity.
Euphorbiaceae Euphorbia yinshanicaent-labdane diterpenes cytotoxic activity
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This work was supported by the National Natural Science Foundation of China (NSFC, Grant No. 31500049) and Postdoctoral Science Foundation of China (2014M552077).
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