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Chemistry of Natural Compounds

, Volume 53, Issue 2, pp 290–294 | Cite as

New Thomimarine E from Marine Isolate of the Fungus Penicillium thomii

  • Sh. Sh. Afiyatullov
  • E. V. Leshchenko
  • M. P. Sobolevskaya
  • A. S. Antonov
  • V. A. Denisenko
  • R. S. Popov
  • Yu. V. Khudyakova
  • N. N. Kirichuk
  • A. S. Kuz’mich
  • E. A. Pislyagin
  • N. Yu. Kim
  • D. V. Berdyshev
Article

The new eudesmane-type sesquiterpene thomimarine E (1) and the known compounds guaiadiol A (2) and 4,10,11-trihydroxyguaiane (3) were isolated from the marine isolate of the fungus Penicillium thomii. The structures of the compounds were established using NMR spectroscopy and high-resolution mass spectrometry. The ability of all compounds to inhibit production of NO in lipopolysaccharide-stimulated murine macrophages (RAW 264.7 line) at nontoxic concentrations was studied.

Keywords

sesquiterpenes Penicillium thomii Zostera marina nitric oxide 

Notes

Acknowledgment

The work was supported financially by the Russian Foundation for Basic Research (RFBR, Project No. 14-04-00910-a) and a stipend from Genzo Shimadzu.

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Sh. Sh. Afiyatullov
    • 1
  • E. V. Leshchenko
    • 1
    • 2
  • M. P. Sobolevskaya
    • 1
  • A. S. Antonov
    • 1
  • V. A. Denisenko
    • 1
  • R. S. Popov
    • 1
  • Yu. V. Khudyakova
    • 1
  • N. N. Kirichuk
    • 1
  • A. S. Kuz’mich
    • 1
  • E. A. Pislyagin
    • 1
  • N. Yu. Kim
    • 1
  • D. V. Berdyshev
    • 1
  1. 1.G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-East BranchRussian Academy of SciencesVladivostokRussian Federation
  2. 2.Far Eastern Federal UniversityVladivostokRussian Federation

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