Chemistry of Natural Compounds

, Volume 53, Issue 2, pp 260–264 | Cite as

Influenza Antiviral Activity of Br-Containing [2R,4R(S),4aR,7R,8aR]-4,7-Dimethyl-2-(Thiophen-2-YL)Octahydro-2H-Chromen-4-Ols Prepared from (–)-Isopulegol

  • E. V. Nazimova
  • A. A. Shtro
  • V. B. Anikin
  • O. S. Patrusheva
  • I. V. Il′ina
  • D. V. Korchagina
  • V. V. Zarubaev
  • K. P. Volcho
  • N. F. Salakhutdinov
Article

Influenza A (H1N1) antiviral activity of compounds with an octahydro-2H-chromene skeleton that were prepared by reacting the monoterpenoid (–)-isopulegol and thiophenecarboxaldehyde and its derivatives was studied for the first time. The 5-bromothiophene-2-carboxaldehyde derivative exhibited the greatest antiviral activity.

Keywords

monoterpenes thiophenecarboxaldehyde clay heterocyclic compounds antiviral activity influenza A 

Notes

Acknowledgment

The research was supported financially by the Russian Science Foundation (Project No. 15-13-00017). We thank the Khimiya Center for Collective Use of the SB RAS for taking the spectral and analytical measurements.

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • E. V. Nazimova
    • 1
  • A. A. Shtro
    • 2
  • V. B. Anikin
    • 2
  • O. S. Patrusheva
    • 1
  • I. V. Il′ina
    • 1
    • 3
  • D. V. Korchagina
    • 1
  • V. V. Zarubaev
    • 2
  • K. P. Volcho
    • 1
    • 3
  • N. F. Salakhutdinov
    • 1
    • 3
  1. 1.N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian BranchRussian Academy of SciencesNovosibirskRussian Federation
  2. 2.Research Institute of Influenza (RII), Ministry of Healthcare of the Russian Federation (MHRF)St. PetersburgRussian Federation
  3. 3.Novosibirsk National Research State UniversityNovosibirskRussian Federation

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