New Fatty Acid From a Gorgonian-Derived Xylaria sp. Fungus
A new fatty acid, (2E,4E,6S)-6-hydroxydeca-2,4-dienoic acid (1), along with six known compounds (2–7), were isolated from the gorgonian-derived fungus Xylaria sp. C-2, collected from the South China Sea. The structure of 1 was elucidated by 1D, 2D NMR, and MS spectrometry. The absolute configuration of 1 was determined by using the modified Mosher’s method. All of the isolated compounds were evaluated for their cytotoxic and antibacterial activities.
Keywordsgorgonian-derived fungus Xylaria sp. C10 unsaturated hydroxy fatty acid absolute configuration
We thank Dr. Chang-Lun Shao, School of Medicine and Pharmacy, Ocean University of China, for sample collection. This work was supported by the National Natural Science Foundation of China (Nos. 81172977; U1406402) and the Special Financial Fund of Innovative Development of Marine Economic Demonstration Project (No. GD2012-D01-001).
- 8.F. J. Arriaga-Giner, E. Wollenweber, I. Schober, and G. Yatskievych, Z. Naturforsch. C, 43, 337 (1988).Google Scholar
- 11.T. Okuno, S. Oikawa, T. Goto, K. Sawai, H. Shirahama, and T. Matsumoto, Agric. Biol. Chem., 50, 997 (1986).Google Scholar
- 12.D. M. Que, H. F. Dai, Y. B. Zeng, J. Wu, and W. L. Mei, Chin. J. Med. Chem., 3, 200 (2009).Google Scholar
- 13.M. Zhang, X. L. Tang, and G. Q. Li, J. Ocean. Univ. China, 5, 89 (2010).Google Scholar