Secondary Metabolites Produced by the Deep-Sea-Derived Fungus Engyodontium album
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Chemical investigation of the EtOH extract of a rice-fermented deep-sea-derived fungal strain, Engyodontium album, led to the isolation of a new benzoic acid derivative, named engyodontiumin A (1), together with four known compounds, 3,4-dihydroxybenzoic acid (2), 3-(2,4-dihydroxyphenyl) propionic acid (3), 3,4-dimethoxybenzoic acid (4), and trans-4-hydroxycinnamic acid (5). This strain was isolated from a marine sediment sample collected in the Atlantic Ocean (24°23′ W, 0°8′N, 3542 m depth). Their structures were elucidated by spectroscopic analyses, including 1H NMR, 13C NMR, 2D NMR (HSQC, HMBC, COSY), and HR-ESI-MS.
KeywordsEngyodontium album engyodontiumin A secondary metabolites
We thank all the members of the Jianming Chen Laboratory for their help and assistance. This work was supported by the Scientific Research Foundation of the Third Institute of Oceanography, SOA (No. 2014007), International Science & Technology Cooperation Program of China (2015DFA20500), Special Financial Fund of Innovative Development of Marine Economic Demonstration Project (GD2012-D01-001), the grants DY125-15-T-03 and DY-125-15-T-08 from the China Ocean Mineral Resources R&D Association, and grant from the Marine Public Welfare Project 201005022.