Chemistry of Natural Compounds

, Volume 53, Issue 2, pp 219–223 | Cite as

Structural Characteristics and Antitumor Activity of Fucoidans from the Brown Alga Sargassum muticum

  • R. V. Usol’tseva
  • Peipei Zhao
  • M. I. Kusaikin
  • Airong Jia
  • Wenpeng Yuan
  • Miansong Zhang
  • Changheng Liu
  • S. P. Ermakova

Water-soluble polysaccharides from two specimens of brown alga Sargassum muticum (April 2014 and June 2015), which synthesized heterogeneous sulfated fucoidans, were isolated and studied. Both specimens produced insignificant amounts of laminarans. Two of three fucoidan fractions from alga collected in April contained mannogalactofucans; one, galactofucan (Fuc–Gal, 2:1). The alga specimen collected in June afforded two galactofucans of different structures (Fuc–Gal, 1:1 and 3:1). Studies of the antitumor activity of the obtained fucoidans and their modified derivatives showed a lack of cytotoxicity and the manifestation of activity against DLD-1 human colon carcinoma cells.


brown algae Sargassum fucoidan structure antitumor activity 



The work was sponsored by RSF Grant No. 16-14-10131.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • R. V. Usol’tseva
    • 1
  • Peipei Zhao
    • 2
  • M. I. Kusaikin
    • 1
  • Airong Jia
    • 2
  • Wenpeng Yuan
    • 2
  • Miansong Zhang
    • 2
  • Changheng Liu
    • 2
  • S. P. Ermakova
    • 1
  1. 1.G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-East BranchRussian Academy of SciencesVladivostokRussia
  2. 2.Biology Institute of Shandong Academy of SciencesJinanP. R. China

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