Advertisement

Chemistry of Natural Compounds

, Volume 53, Issue 2, pp 219–223 | Cite as

Structural Characteristics and Antitumor Activity of Fucoidans from the Brown Alga Sargassum muticum

  • R. V. Usol’tseva
  • Peipei Zhao
  • M. I. Kusaikin
  • Airong Jia
  • Wenpeng Yuan
  • Miansong Zhang
  • Changheng Liu
  • S. P. Ermakova
Article

Water-soluble polysaccharides from two specimens of brown alga Sargassum muticum (April 2014 and June 2015), which synthesized heterogeneous sulfated fucoidans, were isolated and studied. Both specimens produced insignificant amounts of laminarans. Two of three fucoidan fractions from alga collected in April contained mannogalactofucans; one, galactofucan (Fuc–Gal, 2:1). The alga specimen collected in June afforded two galactofucans of different structures (Fuc–Gal, 1:1 and 3:1). Studies of the antitumor activity of the obtained fucoidans and their modified derivatives showed a lack of cytotoxicity and the manifestation of activity against DLD-1 human colon carcinoma cells.

Keywords

brown algae Sargassum fucoidan structure antitumor activity 

Notes

Acknowledgment

The work was sponsored by RSF Grant No. 16-14-10131.

References

  1. 1.
    P. A. Mourao, Curr. Pharm. Des., 10, 967 (2004).CrossRefPubMedGoogle Scholar
  2. 2.
    N. E. Ustyuzhanina, N. A. Ushakova, K. A. Zyuzina, M. I. Bilan, A. L. Elizarova, O. V. Somonova, A. V. Madzhuga, V. B. Krylov, M. E. Preobrazhenskaya, A. I. Usov, M. V. Kislevskiy, and N. E. Nifantiev, Mar. Drugs., 11, 2444 (2013).CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    S. K. Min, S. M. Han, H. T. Kim, O. C. Kwon, S. Lee, and J. K. Kim, Blood Coagul. Fibrinolysis, 23, 359 (2012).CrossRefPubMedGoogle Scholar
  4. 4.
    T. Nishino, T. Yamauchi, M. Horie, T. Nagumo, and H. Suzuki, Thromb. Res., 99, 623 (2000).CrossRefPubMedGoogle Scholar
  5. 5.
    S. Ermakova, R. Sokolova, S. M. Kim, B. H. Um, V. Isakov, and T. Zvyagintseva, Appl. Biochem. Biotechnol., 164, 841 (2011).CrossRefPubMedGoogle Scholar
  6. 6.
    O. S. Vishchuk, S. P. Ermakova, and T. N. Zvyagintseva, Carbohydr. Res., 346, 2769 (2011).CrossRefPubMedGoogle Scholar
  7. 7.
    B. Li, F. Lu, X. Wei, and R. Zhao, Molecules, 13, 1671 (2008).CrossRefPubMedGoogle Scholar
  8. 8.
    M. I. Kusaykin, I. Yu. Bakunina, V. V. Sova, S. P. Ermakova, T. S. Kuznetsova, N. N. Besednova, T. S. Zaporozhets, and T. N. Zvyagintseva, Biotechnol. J., 3, 904 (2008).CrossRefPubMedGoogle Scholar
  9. 9.
    A. I. Usov and M. I. Bilan, Usp. Khim., 78, 846 (2009).CrossRefGoogle Scholar
  10. 10.
    A. I. Usov, G. P. Smirnova, and N. G. Klochkova, Russ. Chem. Bull., 54, 1282 (2005).CrossRefGoogle Scholar
  11. 11.
    J. B. Lee, K. Hayashi, M. Hashimoto, T. Nakano, and T. Hayashi, Chem. Pharm. Bull., 52, 1091 (2004).CrossRefPubMedGoogle Scholar
  12. 12.
    C. H. Xue, Y. Fang, H. Lin, L. Chen, Z. J. Li, D. Deng, and C. X. Lu, J. Appl. Phycol., 13, 67 (2001).CrossRefGoogle Scholar
  13. 13.
    H. M. Shevchenko, S. D. Anastyuk, N. I. Gerasimenko, P. S. Dmitrenok, V. V. Isakov, and T. N. Zvyagintseva, Bioorg. Khim., 33, 96 (2007).PubMedGoogle Scholar
  14. 14.
    W. Zhu, V. E. Ooi, P. K. Chan, and P. O. Ang, Jr., Biochem. Cell Biol., 81, 25 (2003).CrossRefPubMedGoogle Scholar
  15. 15.
    H. D. Cuong, T. T. Thuy, T. T. Huong, B. M. Ly, and T. T. Van, Nat. Prod. Res., 29, 411 (2015).CrossRefPubMedGoogle Scholar
  16. 16.
    S. Preeprame, K. Hayashi, J. B. Lee, U. Sankawa, and T. Hayashi, Chem. Pharm. Bull., 49, 484 (2001).CrossRefPubMedGoogle Scholar
  17. 17.
    M. I. Bilan, A. A. Grachev, A. S. Shashkov, T. T. Thuy, T. T. Van, B. M. Ly, N. E. Nifantiev, and A. I. Usov, Carbohydr. Res., 377, 48 (2013).CrossRefPubMedGoogle Scholar
  18. 18.
    P. Hu, R. Xue, Z. Li, M. Chen, Z. Sun, J. Jiang, and C. Huang, Carbohydr. Res., 390, 28 (2014).CrossRefPubMedGoogle Scholar
  19. 19.
    D. Rodrigues, A. C. Freitas, L. Pereira, T. A. Rocha-Santos, M. W. Vasconcelos, M. Roriz, L. M. Rodriguez-Alcala, A. M. Gomes, and A. C. Duarte, Food Chem., 183, 197 (2015).CrossRefPubMedGoogle Scholar
  20. 20.
    M. Dubois, K. A. Gilles, J. K. Hamilton, P. A. Rebers, and F. Smith, Anal. Chem., 28, 350 (1956).CrossRefGoogle Scholar
  21. 21.
    M. M. Bradford, Anal. Biochem., 72, 248 (1976).CrossRefPubMedGoogle Scholar
  22. 22.
    V. L. Singleton and J. A. Rossi, Am. J. Enol. Vitic., 16, 144 (1965).Google Scholar
  23. 23.
    K. S. Dodgson and R. G. Price, Biochem. J., 84, 106 (1962).CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • R. V. Usol’tseva
    • 1
  • Peipei Zhao
    • 2
  • M. I. Kusaikin
    • 1
  • Airong Jia
    • 2
  • Wenpeng Yuan
    • 2
  • Miansong Zhang
    • 2
  • Changheng Liu
    • 2
  • S. P. Ermakova
    • 1
  1. 1.G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-East BranchRussian Academy of SciencesVladivostokRussia
  2. 2.Biology Institute of Shandong Academy of SciencesJinanP. R. China

Personalised recommendations