Prenylated Dihydrostilbenes from Macaranga rubiginosa
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Phytochemical isolation of the methanol extract of Macaranga rubiginosa leaves afforded five prenylated dihydrostilbenes. Two of them were known dihydrostilbenes laevifolins A (1) and B (2), while the other three were new compounds, trivially named macarubiginosins A–C (3–5). The structures of the new compounds were elucidated based on their UV, 1D and 2D NMR, and HR-ESI-MS spectral data. Compounds 1–5 were tested for their cytotoxicity against P-388 cells, showing that compound 1 was the most active with IC50 4.3 μM.
Keywordsmacarubiginosins A–C laevifolins A and B prenylated dihydrostilbenes Macaranga rubiginosa Euphorbiaceae cytotoxicity P-388 cells
Part of this work is supported by the KK Research Grant (Contract No. 1763/I1.B04.1/KU/2015), Bandung Institute of Technology. The authors also thank the staff of Herbarium Bogoriense, Center of Biological Research and Development, National Institute of Science, Bogor, Indonesia, for identification of the plant specimen.
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