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Coumarins from the Leaves of Nicotiana tabacum and Their Anti-Tobacco Mosaic Virus Activities

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Chemistry of Natural Compounds Aims and scope

Two new coumarins, 6-hydroxy-7-methyl-3-(4′-methoxyphenyl)-coumarin (1) and 6-hydroxy-5-methoxy-7-methyl-3-(4′-methoxyphenyl)-coumarin (2), together with five known coumarins (3–7), were isolated from the leaves of Nicotiana tabacum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1–7 were tested for their anti-tobacco mosaic virus (anti-TMV) activities. Compound 2 showed high anti-TMV activity with inhibition rate of 28.6%. This rate is close to that of the positive control. The other compounds also showed potential anti-TMV activity with inhibition rates in the ranges of 13.7–23.2%, respectively.

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Acknowledgment

This research was supported by the National Natural Science Foundation of China (No. 31360081), the Basic Research Foundation of Yunnan Province (2013FB097), and the Basic Research Foundation of Yunnan Tobacco Industry Co. Ltd (2012JC01).

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Authors and Affiliations

  1. Key Laboratory of Tobacco Chemistry of Yunnan Province, Research and Development Center, China Tobacco Yunnan Industrial Co., Ltd., 650231, Kunming, P. R. China

    Chun-Bo Liu, Qin-Peng Shen, Yun Wang, Feng-Mei Zhang, Pei He, Xiao-Xi Si, Kun-Miao Wang, Rui-Zhi Zhu, Neng-Jun Xiang & Zhi-Hua Liu

  2. School of Chemical Science and Technology, Yunnan University, 650091, Kunming, P. R. China

    Yun Wang

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  1. Chun-Bo Liu
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Correspondence to Neng-Jun Xiang or Zhi-Hua Liu.

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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2016, pp. 852–854.

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Liu, CB., Shen, QP., Wang, Y. et al. Coumarins from the Leaves of Nicotiana tabacum and Their Anti-Tobacco Mosaic Virus Activities. Chem Nat Compd 52, 992–995 (2016). https://doi.org/10.1007/s10600-016-1844-8

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  • DOI: https://doi.org/10.1007/s10600-016-1844-8

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