Chemistry of Natural Compounds

, Volume 52, Issue 5, pp 961–962 | Cite as

Structure–Activity Relationship of Epimeric 3,17-Substituted 5α-Androstane Aminoalcohols

  • N. Sh. Nadaraia
  • L. Sh. Amiranashvili
  • M. I. Merlani

Several aminosteroids exhibit high non-hormonal biological activity and are used to synthesize derivatives with a variety of physiological activity including antiarrhythmic, antidepressant, and antitumor properties [1, 2, 3, 4].

Natural and synthetic amino derivatives are found among numerous radioprotectors [5]. The radioprotective activity (RPA) of alicyclic aromatic and heterocyclic amines, aminothiols, and aminoalkylthiosulfates is well studied. Information regarding the RPA of steroids is rather sparse and limited to a few examples [6, 7].

The structure–activity relationship of epiandrosterone 1 and androsterone 2, transformation products of tigogenin, was studied by us earlier [ 8, 9] by synthesizing 5 α-androstane aminoalcohols 310.


Hydrobromide Heterocyclic Amine Antiarrhythmic Activity Amino Derivative Aconitine 
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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • N. Sh. Nadaraia
    • 1
  • L. Sh. Amiranashvili
    • 1
  • M. I. Merlani
    • 1
  1. 1.I. Kutateladze Institute of Pharmaceutical ChemistryTbilisi State Medical UniversityTbilisiGeorgia

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