Structure–Activity Relationship of Epimeric 3,17-Substituted 5α-Androstane Aminoalcohols
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Several aminosteroids exhibit high non-hormonal biological activity and are used to synthesize derivatives with a variety of physiological activity including antiarrhythmic, antidepressant, and antitumor properties [1, 2, 3, 4].
Natural and synthetic amino derivatives are found among numerous radioprotectors . The radioprotective activity (RPA) of alicyclic aromatic and heterocyclic amines, aminothiols, and aminoalkylthiosulfates is well studied. Information regarding the RPA of steroids is rather sparse and limited to a few examples [6, 7].
KeywordsHydrobromide Heterocyclic Amine Antiarrhythmic Activity Amino Derivative Aconitine
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