Advertisement

Chemistry of Natural Compounds

, Volume 52, Issue 5, pp 961–962 | Cite as

Structure–Activity Relationship of Epimeric 3,17-Substituted 5α-Androstane Aminoalcohols

  • N. Sh. Nadaraia
  • L. Sh. Amiranashvili
  • M. I. Merlani
Article
  • 33 Downloads

Several aminosteroids exhibit high non-hormonal biological activity and are used to synthesize derivatives with a variety of physiological activity including antiarrhythmic, antidepressant, and antitumor properties [1, 2, 3, 4].

Natural and synthetic amino derivatives are found among numerous radioprotectors [5]. The radioprotective activity (RPA) of alicyclic aromatic and heterocyclic amines, aminothiols, and aminoalkylthiosulfates is well studied. Information regarding the RPA of steroids is rather sparse and limited to a few examples [6, 7].

The structure–activity relationship of epiandrosterone 1 and androsterone 2, transformation products of tigogenin, was studied by us earlier [ 8, 9] by synthesizing 5 α-androstane aminoalcohols 310.

Keywords

Hydrobromide Heterocyclic Amine Antiarrhythmic Activity Amino Derivative Aconitine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    S. D. Taylor and J. Harris, Steroids, 76, 1098 (2011).CrossRefPubMedGoogle Scholar
  2. 2.
    D. Thibeault, J. Roy, P. DeRoy, and D. Poirier, Bioorg. Med. Chem., 16 (9), 5062 (2008).CrossRefPubMedGoogle Scholar
  3. 3.
    M. Mokotoff, M. Zhao, R. J. Marshall, E. Winslow, L. K. Wang, and Q. J. Liaot, Steroids, 55, 399 (1990).CrossRefPubMedGoogle Scholar
  4. 4.
    T. J. Campbell and E. M. V. Williams, Br. J. Pharmacol., 76, 337 (1982).CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    N. N. Suvorov and V. S. Shashkov, Chemistry and Pharmacology of Radiation Protection Drugs [in Russian], Moscow, 1975, p. 224.Google Scholar
  6. 6.
    R. D. Elliot, J. R. Piper, C. R. Stringfellow, and T. S. Johnston, J. Med. Chem., 15, 595 (1972).CrossRefGoogle Scholar
  7. 7.
    M. Berstein, H. Ginsberg, and J. Glen, Neurosurgery, 31 (5), 923 (1992).CrossRefGoogle Scholar
  8. 8.
    8. N. Sh. Nadaraia, V. I. Sladkov, E. V. Dorodnikova, M. D. Mashkovskii, E. P. Kemertelidze, and N. N. Suvorov, Khim.-farm. Zh., 22 (3), 288 (1988).Google Scholar
  9. 9.
    L. Sh. Amiranashvili, V. I. Sladkov, N. I. Men’shova, E. P. Kemertelidze, and N. N. Suvorov, Soobshch. Akad. Nauk Gruz. SSR, 138 (1), 85 (1990).Google Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • N. Sh. Nadaraia
    • 1
  • L. Sh. Amiranashvili
    • 1
  • M. I. Merlani
    • 1
  1. 1.I. Kutateladze Institute of Pharmaceutical ChemistryTbilisi State Medical UniversityTbilisiGeorgia

Personalised recommendations