Advertisement

Chemistry of Natural Compounds

, Volume 52, Issue 5, pp 853–855 | Cite as

Synthesis and Antiviral Activity of Several N-Containing 5α-STEROIDS

  • N. Sh. Nadaraia
  • E. O. Onashvili
  • M. L. Kakhabrishvili
  • N. N. Barbakadze
  • B. Sylla
  • A. Pichette
Article

A study of the antiviral activity of several new hydrazones and amines and amides of 5α-steroids that were synthesized by us earlier found highly and moderately active compounds. The structures of the synthesized compounds were proven using IR, PMR, 13C NMR, and mass spectral data.

Keywords

5α-steroids synthesis hydrazides hydrazones amines amides antiviral activity 

References

  1. 1.
    A. H. Banday, S. A. Shameem, and S. Jeelani, Steroids, 92, 13 (2014).CrossRefPubMedGoogle Scholar
  2. 2.
    N. Deive, J. Rodriguez, and C. Jimenez, J. Med. Chem., 44 (16), 2612 (2001).CrossRefPubMedGoogle Scholar
  3. 3.
    M. I. Choudhary, M. S. Alam, A. Rahman, S. Yousuf, Y. C. Wu, A. S. Lin, and F. Shaheen, Steroids, 76, 1554 (2011).CrossRefGoogle Scholar
  4. 4.
    C. Gan, J. Cui, Sh. Su, Q. Lin, L. Jia, L. Fan, and Y. Huang, Steroids, 87, 99 (2014).CrossRefPubMedGoogle Scholar
  5. 5.
    Y. Huang, J. Cui, L. Jia, C. Gan, H. Song, C. Zeng, and A. Zhou, Molecules, 18, 7436 (2013).CrossRefPubMedGoogle Scholar
  6. 6.
    J. Cui, L. Liu, D. Zhao, C. Gan, X. Huang, Q. Xiao, B. Qi, L. Yang, and Y. Huang, Steroids, 95, 32 (2015).CrossRefPubMedGoogle Scholar
  7. 7.
    M. I. Merlani, L. Sh. Amiranashvili, E. P. Kemertelidze, and K. G. Mulkidzhanyan, Chem. Nat. Compd., 45, 389 (2009).CrossRefGoogle Scholar
  8. 8.
    S. D. Taylor and J. Harris, Steroids, 76, 1098 (2011).CrossRefPubMedGoogle Scholar
  9. 9.
    M. I. Sikharulidze, N. Sh. Nadaraia, M. L. Kakhabrishvili, N. N. Barbakadze, and K. G. Mulkidzhanyan, Chem. Nat. Compd., 46, 493 (2010).CrossRefGoogle Scholar
  10. 10.
    M. I. Sikharulidze, N. Sh. Nadaraia, and M. L. Kakhabrishvili, Chem. Nat. Compd., 48, 423 (2012).CrossRefGoogle Scholar
  11. 11.
    M. I. Merlani, M. G. Davitishvili, N. Sh. Nadaraia, M. I. Sikharulidze, and K. Papadopulos, Chem. Nat. Compd., 40, 144 (2004).CrossRefGoogle Scholar
  12. 12.
    M. I. Sikharulidze, N. Sh. Nadaraia, M. L. Kakhabrishvili, and N. N. Barbakadze, Sb. Tr. Tbilissk. Gos. Med. Univ., 46, 148 (2012).Google Scholar
  13. 13.
    N. Sh. Nadaraia, M. L. Kakhabrishvili, N. N. Barbakadze, and M. I. Sikharulidze, Khim. Zh. Gruz., 13 (1), 146 (2013).Google Scholar
  14. 14.
    N. I. Men′shova, N. A. Korzinkina, E. P. Kemertelidze, N. Sh. Nadaraia, M. G. Davitishvili, L. I. Lishcheta, and V. S. Grosheva, Sb. Nauchn. Tr. VNIKhFI, 10, 83 (1982).Google Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • N. Sh. Nadaraia
    • 1
  • E. O. Onashvili
    • 1
  • M. L. Kakhabrishvili
    • 1
  • N. N. Barbakadze
    • 1
  • B. Sylla
    • 2
  • A. Pichette
    • 2
  1. 1.I. Kutateladze Institute of Pharmaceutical ChemistryTbilisi State Medical UniversityTbilisiGeorgia
  2. 2.LASEVE, Universite Quebec a ChicoutimChicoutimiCanada

Personalised recommendations