Secondary Metabolites from an Endophytic Fungus Nigrospora sp.
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Endophytic microorganisms are found in virtually every plant on earth. Natural products from endophytic fungi have been observed to inhibit or kill a wide variety of harmful microorganisms including, but not limited to, phytopathogens, as well as bacteria, fungi, viruses, and protozoans that affect humans and animals . Fungi belonging to the genus Nigrospora have been a rich source of bioactive secondary metabolites, such as plant growth-inhibiting nigrosporolide and phomalactone, phytotoxic and antibacterial nigrosporins, and phytotoxic lactones . During our continuous chemical investigation of endophytic fungi, we have studied the secondary metabolites of Nigrospora sp. YE 3033 isolated from Aconitum carmichaelii and obtained nine compounds.
The fungal strain Nigrospora sp. YE 3033 was isolated from the root of A. carmichaelii collected in Yunnan Province, P. R. China. It was classified as a Nigrosporaspecies by its morphological characteristics and ITS rDNA sequence...
KeywordsMeOH Minimal Inhibition Concentration EtOAc CD3OD Endophytic Fungus
This work was supported by grants from the National Natural Science Foundation of China (Program Nos. 81460545 and 21062027), and the Natural Science Foundation of Yunnan Province (Program No. 2010CD009).
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