New Diorcinol J Produced by Co-Cultivation of Marine Fungi Aspergillus sulphureus and Isaria felina
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New diorcinol J (1) and four known diorcinols B-E (2-5) were isolated from the EtOAc extract of a co-culture of marine isolates of the fungi Aspergillus sulphureus KMM 4640 and Isaria felina KMM 4639. The structure of diorcinol J was established using NMR spectroscopy and high-resolution mass spectrometry. The cytotoxicity of the isolated compounds and their ability to enhance expression of heat shock protein Hsp70 in Ehrlich ascites carcinoma cells were investigated.
Keywordsdiorcinol co-cultivation marine fungi Aspergillus sulphureus Isaria felina cytotoxicity
The work was sponsored by the Russian Foundation for Basic Research (grants 14-04-00910-a, 14-04-32052-mol_a, 15-29-02572/15-ofi_m), the Scientific Foundation of Far-East Federal University (Project No. 14-08-01-34_i), and RAS FEB Program “Far East” (Project No. 15-II-5-017).
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