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Chemistry of Natural Compounds

, Volume 52, Issue 2, pp 227–230 | Cite as

New Diorcinol J Produced by Co-Cultivation of Marine Fungi Aspergillus sulphureus and Isaria felina

  • O. I. Zhuravleva
  • N. N. Kirichuk
  • V. A. Denisenko
  • P. S. Dmitrenok
  • E. A. Yurchenko
  • E. M. Min′ko
  • E. V. Ivanets
  • Sh. Sh. Afiyatullov
Article

New diorcinol J (1) and four known diorcinols B-E (2-5) were isolated from the EtOAc extract of a co-culture of marine isolates of the fungi Aspergillus sulphureus KMM 4640 and Isaria felina KMM 4639. The structure of diorcinol J was established using NMR spectroscopy and high-resolution mass spectrometry. The cytotoxicity of the isolated compounds and their ability to enhance expression of heat shock protein Hsp70 in Ehrlich ascites carcinoma cells were investigated.

Keywords

diorcinol co-cultivation marine fungi Aspergillus sulphureus Isaria felina cytotoxicity 

Notes

Acknowledgment

The work was sponsored by the Russian Foundation for Basic Research (grants 14-04-00910-a, 14-04-32052-mol_a, 15-29-02572/15-ofi_m), the Scientific Foundation of Far-East Federal University (Project No. 14-08-01-34_i), and RAS FEB Program “Far East” (Project No. 15-II-5-017).

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • O. I. Zhuravleva
    • 1
    • 2
  • N. N. Kirichuk
    • 1
  • V. A. Denisenko
    • 1
  • P. S. Dmitrenok
    • 1
  • E. A. Yurchenko
    • 1
  • E. M. Min′ko
    • 2
  • E. V. Ivanets
    • 2
  • Sh. Sh. Afiyatullov
    • 1
  1. 1.G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-East BranchRussian Academy of SciencesVladivostokRussian Federation
  2. 2.Far-East Federal UniversityVladivostokRussia

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