New Diorcinol J Produced by Co-Cultivation of Marine Fungi Aspergillus sulphureus and Isaria felina
New diorcinol J (1) and four known diorcinols B-E (2-5) were isolated from the EtOAc extract of a co-culture of marine isolates of the fungi Aspergillus sulphureus KMM 4640 and Isaria felina KMM 4639. The structure of diorcinol J was established using NMR spectroscopy and high-resolution mass spectrometry. The cytotoxicity of the isolated compounds and their ability to enhance expression of heat shock protein Hsp70 in Ehrlich ascites carcinoma cells were investigated.
Keywordsdiorcinol co-cultivation marine fungi Aspergillus sulphureus Isaria felina cytotoxicity
The work was sponsored by the Russian Foundation for Basic Research (grants 14-04-00910-a, 14-04-32052-mol_a, 15-29-02572/15-ofi_m), the Scientific Foundation of Far-East Federal University (Project No. 14-08-01-34_i), and RAS FEB Program “Far East” (Project No. 15-II-5-017).
- 6.Sh. Sh. Afiyatullov, T. A. Kuznetsova, V. V. Isakov, M. V. Pivkin, N. G. Prokof′eva, and G. B. Elyakov, J. Nat. Prod., 63, 848 (2000).Google Scholar