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Chemistry of Natural Compounds

, Volume 51, Issue 5, pp 999–1000 | Cite as

Diverse Terpenoids from the Leaves of Clerodendrum trichotomum

  • Rui-Lan Xu
  • Hai-Long Jiang
  • Rui Wang
  • Yan-Ping Shi
Article
  • 84 Downloads

Clerodendrum trichotomum Thunb., whose leaves and twigs are known in Chinese as “Chou-Wu-Tong” due to the unpleasant smell, belongs to the Verbenaceae family. Its roots, stems, leaves, flowers, and fruits have been used as medicine due to their antihypertensive, sedative, analgesic, and anti-inflammatory properties [1]. Pharmacological studies on this plant have suggested that the diterpenoids exhibit distinct feeding stimulant activity to the adult turnip sawfly [2] and that these triterpenoids have potential as an antibacterial agent [3]. In the course of our study on the systematic chemical constituents of the EtOH extract of the leaves of C. trichotomum, a series of steroids [4] and cyclohexylethanoids [5], together with diverse terpenoids (1–15), including monoterpenoids, sesquiterpenoids, diterpenoids, and triterpenoids, were isolated and elucidated by a comprehensive analysis of the spectral data, including NMR and ESI-MS, and comparison of their NMR data with those in the...

Keywords

CDCl3 EtOH Gansu Province Betulinic Acid Lupeol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

This work was supported by the National Natural Science Foundation of China (Nos. 21375136 and 81303202).

References

  1. 1.
    L. R. Song, Chinese Materia Medica, Shanghai Science and Technology Press, Shanghai, 18, 1999, pp. 5959–5960.Google Scholar
  2. 2.
    K. Kawai, T. Amano, R. Nishida, Y. Kuwahara, and H. Fukami, Phytochemistry, 49 (7), 1975 (1998).CrossRefGoogle Scholar
  3. 3.
    J. W. Choi, E. J. Cho, D. G. Lee, K. Choi, J. Ku, K. W. Park, and S. Lee, J. Appl. Biol. Chem., 55 (3), 169 (2012).CrossRefGoogle Scholar
  4. 4.
    R. L. Xu, R. Wang, L. Ding, and Y. P. Shi, Steroids, 78 (7), 711 (2013).CrossRefPubMedGoogle Scholar
  5. 5.
    R. L. Xu, R. Wang, W. Ha, and Y. P. Shi, Phytochem. Lett., 7, 111 (2014).CrossRefGoogle Scholar
  6. 6.
    X. L. Li, S. H. Xu, X. C. Zeng, S. H. Guo, D. H. He, and K. Yang, Chin. J. Org. Chem., 24 (9), 1060 (2004).Google Scholar
  7. 7.
    B. Yang, J. Hu, H. Lei, X. Q. Chen, X. F. Zhou, and Y. H. Liu, Chem. Nat. Compd., 48, 350 (2012).CrossRefGoogle Scholar
  8. 8.
    F. A. Macias, R. M. Oliva, R. M. Varela, A. Torres, and J. M. Molinillo, Phytochemistry, 52 (4), 613 (1999).CrossRefGoogle Scholar
  9. 9.
    I. H. Calis, A. Kuruuzum Uz, P. A. Lorenzetto, and P. Ruedi, Phytochemistry, 59 (4), 451 (2002).CrossRefPubMedGoogle Scholar
  10. 10.
    C. C. Wei, X. D. Wang, and X. Li, Chem. Nat. Compd., 48, 1098 (2013).CrossRefGoogle Scholar
  11. 11.
    A. Fiorentino, B. D′Abrosca, S. Pacifico, M. Scognamiglio, G. D′Angelo, and P. Monaco, Bioorg. Med. Chem., 18 (24), 8530 (2010).CrossRefPubMedGoogle Scholar
  12. 12.
    A. Ulubelen, G. Topcu, and S. Olcal, Phytochemistry, 37 (5), 1371 (1994).CrossRefGoogle Scholar
  13. 13.
    M. Hasan, D. K. Burdi, and V. U. Ahmad, J. Nat. Prod., 54 (5), 1444 (1991).CrossRefGoogle Scholar
  14. 14.
    M. Norte, M. L. Souto, and J. J. Fernandez, Nat. Prod. Lett., 8 (4), 263 (1996).CrossRefGoogle Scholar
  15. 15.
    J. S. Kim, Y. J. Kim, J. Y. Lee, and S. S. Kang, Korean J. Pharmacogn., 39 (1), 28 (2008).Google Scholar
  16. 16.
    Y. M. Luo, A. H. Liu, B. W. Yu, L. J. Kang, and L. Q. Huang, Chin. Pharm. J., 40 (17), 1296 (2005).Google Scholar
  17. 17.
    A. Yili, H. A. Aisa, and M. I. Isaev, Chem. Nat. Compd., 45, 592 (2009).CrossRefGoogle Scholar
  18. 18.
    Y. Li, Y. Q. Wu, and Y. P. Shi, Pharmazie, 58 (12), 937 (2003).PubMedGoogle Scholar
  19. 19.
    T. S. Li, T. H. Beveridge, and J. C. Drover, Food. Chem., 101 (4), 1633 (2007).CrossRefGoogle Scholar
  20. 20.
    D. H. Kim, K. M. Han, I. S. Chung, D. K. Kim, S. H. Kim, B. M. Kwon, T. S. Jeong, M. H. Park, E. M. Ahn, and N. I. Baek, Arch. Pharm. Res., 28 (5), 550 (2005).CrossRefPubMedGoogle Scholar
  21. 21.
    D. Y. Lee, L. Jung, J. H. Park, K. H. Yoo, I. S. Chung, and N. I. Baek, Chem. Nat. Compd., 46, 142 (2010).CrossRefGoogle Scholar
  22. 22.
    Y. Huang, H. A. Aisa, and M. I. Isaev, Chem. Nat. Compd., 45, 921 (2009).CrossRefGoogle Scholar
  23. 23.
    G. de Fatima Lemes, P. H. Ferri, and M. N. Lopes, Quim. Nova, 34 (1), 39 (2011).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Rui-Lan Xu
    • 1
    • 2
  • Hai-Long Jiang
    • 1
  • Rui Wang
    • 1
  • Yan-Ping Shi
    • 1
  1. 1.Key Laboratory of Chemistry of Northwestern Plant Resources of the CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhouP. R. China
  2. 2.University of Chinese Academy of SciencesBeijingP. R. China

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