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Chemistry of Natural Compounds

, Volume 51, Issue 5, pp 910–915 | Cite as

Synthesis and Nootropic Activity of new 3-Amino-12-N-Methylcytisine Derivatives

  • I. P. Tsypysheva
  • A. V. Koval’skaya
  • A. N. Lobov
  • N. S. Makara
  • P. R. Petrova
  • E. I. Farafontova
  • L. F. Zainullina
  • Yu. V. Vakhitova
  • F. S. Zarudii
Article

Reductive alkylation of 3-amino-12-N-methylcytisine by aromatic aldehydes synthesized a series of secondary amines. The nootropic activity of the synthesized compounds was studied in vivo (mnestic and antihypoxic properties) and in vitro (antiradical properties and ability to affect transcription factor HIF-1 DNA-binding activity). The cytotoxicity of the synthesized compounds was assessed. The lead compound was identified.

Keywords

(–)-cytisine nootropic activity mnestic effect antihypoxic properties antiradical properties AOS TF HIF-1 

Notes

Acknowledgment

The work used equipment at the Biomika CCU (Department of Biochemical Research Methods and Nanobiotechnology, RTsKP Agidel, Ufa) and UNU KODINK. The work was sponsored by the RAS Presidium Basic Research Program “Basic Sciences – Medicine” for 2014; grants of the RF President for leading scientific schools NSh-5923.2014.4; and RFBR Grant No. 14-04-97035-povolzh'e-a.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • I. P. Tsypysheva
    • 1
  • A. V. Koval’skaya
    • 1
  • A. N. Lobov
    • 1
  • N. S. Makara
    • 1
  • P. R. Petrova
    • 1
    • 3
  • E. I. Farafontova
    • 2
  • L. F. Zainullina
    • 2
  • Yu. V. Vakhitova
    • 2
  • F. S. Zarudii
    • 1
    • 4
  1. 1.Ufa Institute of ChemistryRussian Academy of SciencesUfaRussia
  2. 2.Institute of Biochemistry and Genetics, Ufa Scientific CenterRussian Academy of SciencesUfaRussia
  3. 3.Bashkir State University, UfaUfaRussia
  4. 4.Bashkir State Medical University, UfaUfaRussia

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