Two New Flavones from Hypericum chinense and Their Anti-Tobacco Mosaic Virus Activity
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Two new flavones, 6,4′-dimethoxy-8-formylflavone (1) and 6,7-dimethoxy-8-acetyl-4′-hydroxyflavone (2), together with five known flavones (3–7), were isolated from the leaves and stems of Hypericum chinense. The structure of 1–7 was elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 1, 2, 6, and 7 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compound 1 shows high anti-TMV activity with an inhibition rate of 31.4%, which is close to that of the positive control.
KeywordsHypericum chinense flavones anti-tobacco mosaic virus
This research was supported by the National Natural Science Foundation of China (No. 21362044), the Excellent Scientific and Technological Team of Yunnan High School (2010CI08), and the Yunnan University of Nationalities Green Chemistry and Functional Materials Research for Provincial Innovation Team (2011HC008).
- 3.Z. Y. Xiao and Q. Mu, Nat. Prod. Res. Dev., 19, 344 (2007).Google Scholar
- 8.Y. Wu, S. D. Zhou, and P. Li, Acta Pharm. Sinica, 37, 562 (2002).Google Scholar
- 10.D. Q. Yu and J. S. Yang, Handbook of Analytical Chemistry (7th vol.), Nuclear Magnetic Resonance Spectroscopy, 2nd Edn., Chemical Industry Press, Beijing, 1999, p. 816.Google Scholar