Chemistry of Natural Compounds

, Volume 51, Issue 2, pp 311–315 | Cite as

A New Megastigmane Alkaloid from Pachysandra terminalis with Antitumor Metastasis Effect

  • Mei-Na Jin
  • Sheng-Nan Ma
  • Hui-Yuan Zhai
  • Nan-Qin
  • Hong-Quan Duan
  • De-Xin Kong

9-(N,N-Dimethyl)-4,7-megastigmedien-3-one (1) was isolated from Pachysandra terminalis and identified by 1D and 2D NMR spectroscopic and mass spectrometric methods. Compound 1 revealed significant anti-metastasis effect on cancer cell migration and invasion through suppressing the expressions of p-PKCζ and p-integrin β1 in human breast cancer cells, and also showed anti-angiogenic activity on human umbilical vein endothelial cells.


megastigmane alkaloid antitumor metastasis p-PKCζ p-integrin βanti-angiogenic activity 



This work was supported by grants from the National Natural Science Foundation of China (NSFC) (81072540) and the Tianjin Research Program of Applied Basic and Cutting-edge Technologies (11JCZDJC20900, 12JCZDJC25800).


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of PharmacyTianjin Medical UniversityTianjinP. R. China
  2. 2.Tianjin 4th Center HospitalTianjinP. R. China
  3. 3.Nanjing Integrated Traditional Chinese and Western Medicine HospitalNanjingP. R. China
  4. 4.Research Center of Basic Medical SciencesTianjin Medical UniversityTianjinP. R. China

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