Phenolic Constituents with Inhibitory Activities on Acetylcholinesterase from the Rhizomes of Gastrodia elata
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Gastrodia elata Blume (Orchidaceae) is a famous traditional Chinese medicine (TCM) used for the treatment of convulsive diseases such as epilepsy . This drug (Chinese name “Tianma”) also has numerous beneficial properties: tranquilizing and allaying excitement; analgesia; expelling toxins; enhancing strength and virility; improving circulation and memory . It is prescribed for headaches, migraines, dizziness, epilepsy, rheumatism, neuralgia, paralysis, and other neuralgic and nervous disorders.
Phytochemical studies on the rhizome of G. elata have reported the composition of volatile compounds  and main phenolic compounds [4, 5, 6]. G. elata has obvious pharmacologic actions on the nervous system, such as tranquilizing and allaying excitement , and neuroprotective properties .
Acetylcholinesterase (AChE) is a serine protease that hydrolyzes the neurotransmitter acetylcholine, and its activity serves to terminate synaptic transmission. The loss of synapses is the major...
KeywordsMigraine Phenolic Compound EtOAc Acetylcholinesterase Tacrine
This work was supported by a Special Fund for Agro-scientific Research in the Public Interest (Grant number 201303117), National Support Science and Technology Subject (2013BAI11B04), the Grand Science and Technology Subject of Hainan (ZDZX2013008-4), and the Fundamental Scientific Research Funds for CATAS (ITBB140401; ITBB110301). The authors thank the members of the analytical group of the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, for spectral measurements.