Chemistry of Natural Compounds

, Volume 51, Issue 1, pp 103–107 | Cite as

Search for Antiviral Agents Among Quinopimaric Acid Scaffold Derivatives

  • G. F. Vafina
  • A. R. Uzbekov
  • V. V. Zarubaev
  • L. A. Karpinskaya
  • A. A. Shtro
  • M. S. Yunusov

Novel quinopimaric acid scaffold derivatives were synthesized. Their antiviral activity against influenza A/California/07/09 (H1N1) was studied. It was found that several of the synthesized quinopimaric acid scaffold derivatives were potentially active etiotropic antiviral compounds.


quinopimaric acid scaffold derivatives influenza A antiviral activity 



The work was sponsored by a grant of the RF President for Support of Leading Scientific Schools NSh-1700.2014.3.


  1. 1.
    W. J. Geldenhuys, S. F. Malan, J. R. Bloomquist, A. P. Marchand, and C. J. Van der Schyf, Med. Res. Rev., 25, 21 (2005).CrossRefPubMedGoogle Scholar
  2. 2.
    O. K. Onajole, Y. Coovadia, T. Govender, H. G. Kruger, G. E. M. Maguire, D. Naidu, N. Singh, and P. Govender, Chem. Biol. Drug Des., 77, 295 (2011).CrossRefPubMedGoogle Scholar
  3. 3.
    B. Honarparvar, M. M. Makatini, S. A. Pawar, K. Petzold, M. E. S. Soliman, P. I. Arvidsson, Y. Sayed, T. Govender, G. E. M. Maguire, and H. G. Kruger, ChemMedChem., 7, 1009 (2012).CrossRefPubMedGoogle Scholar
  4. 4.
    G. F. Vafina, A. R. Uzbekov, F. Z. Galin, and M. S. Yunusov, Chem. Nat. Compd., 49, 1035 (2014).CrossRefGoogle Scholar
  5. 5.
    G. F. Vafina, A. R. Uzbekov, L. V. Spirikhin, and M. S. Yunusov, Chem. Nat. Compd., 49, 645 (2013).CrossRefGoogle Scholar
  6. 6.
    K. Nagayama, A. Kumar, K. Wuthrich, and R. R. Ernst, J. Magn. Reson., 40, 321 (1980).Google Scholar
  7. 7.
    A. L. Davis, J. Keeler, E. D. Laue, and D. Moskau, J. Magn. Reson., 98, 207 (1992).Google Scholar
  8. 8.
    R. E. Hurd and B. K. John, J. Magn. Reson., 91, 648 (1991).Google Scholar
  9. 9.
    J. Jeener, B. H. Meier, P. Bachmann, and R. R. Ernst, J. Chem. Phys., 71, 4546 (1979).CrossRefGoogle Scholar
  10. 10.
    T. Mosmann, J. Immunol. Methods, 16, 55 (1983).CrossRefGoogle Scholar
  11. 11.
    V. V. Zarubaev, E. L. Golod, P. M. Anfimov, A. A. Shtro, V. V. Saraev, A. S. Gavrilov, A. V. Logvinov, and O. I. Kiselev, Bioorg. Med. Chem., 18, 839 (2010).CrossRefPubMedGoogle Scholar
  12. 12.
    I. P. Tsypysheva, A. V. Kovalskaya, A. N. Lobov, V. V. Zarubaev, L. A. Karpinskaya, I. A. Petrenko, E. A. Nikolaeva, A. A. Shtro, and M. S. Yunusov, Chem. Nat. Compd., 48, 1042 (2013).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • G. F. Vafina
    • 1
  • A. R. Uzbekov
    • 1
  • V. V. Zarubaev
    • 2
  • L. A. Karpinskaya
    • 2
  • A. A. Shtro
    • 2
  • M. S. Yunusov
    • 1
  1. 1.Institute of Organic Chemistry, Ufa Scientific CenterRussian Academy of SciencesUfaRussia
  2. 2.Influenza Research InstituteRussian Federation Ministry of Health and Social DevelopmentSt. PetersburgRussia

Personalised recommendations