Chemistry of Natural Compounds

, Volume 51, Issue 1, pp 43–46 | Cite as

Coumarins from the Roots and Stems of Nicotiana tabacum and their Anti-Tobacco Mosaic Virus Activity

  • Chun Lei
  • Wenxiu Xu
  • Jia Wu
  • Sujuan Wang
  • Ji-Qing Sun
  • Zhangyu Chen
  • Guangyu Yang

Two new coumarins, 7-(4-hydroxyphenyl)-6H-[1, 3]dioxolo[4,5-g]chromen-6-one (1) and 7-(2-hydroxy-3,4-dimethoxyphenyl)-6H-[1,3]dioxolo[4,5-g]chromen-6-one (2), together with five known coumarins (3–7), were isolated from the roots and stems of flue-cured tobacco (a variety of Nicotiana tabacum L.). Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (anti-TMV) activity, and they show potential anti-TMV activity with inhibition rates of 14.5 and 31.2%, respectively.


flue-cured tobacco coumarins anti-tobacco mosaic virus 



This project was supported financially by the Basic Research Foundation of Yunnan Tobacco Industry Co. Ltd. (2012JC01) and the National Natural Science Foundation of China (No. 21002085).


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© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Pharmacognosy, School of PharmacyFudan UniversityShanghaiP. R. China
  2. 2.Key Laboratory of Tobacco Chemistry of Yunnan ProvinceYunnan Academy of Tobacco ScienceKunmingP. R. China

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