Coumarins from the Roots and Stems of Nicotiana tabacum and their Anti-Tobacco Mosaic Virus Activity
- 140 Downloads
Two new coumarins, 7-(4-hydroxyphenyl)-6H-[1, 3]dioxolo[4,5-g]chromen-6-one (1) and 7-(2-hydroxy-3,4-dimethoxyphenyl)-6H-[1,3]dioxolo[4,5-g]chromen-6-one (2), together with five known coumarins (3–7), were isolated from the roots and stems of flue-cured tobacco (a variety of Nicotiana tabacum L.). Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (anti-TMV) activity, and they show potential anti-TMV activity with inhibition rates of 14.5 and 31.2%, respectively.
Keywordsflue-cured tobacco coumarins anti-tobacco mosaic virus
This project was supported financially by the Basic Research Foundation of Yunnan Tobacco Industry Co. Ltd. (2012JC01) and the National Natural Science Foundation of China (No. 21002085).
- 1.The Editorial Committee of the Administration Bureau of Flora of China, Flora of China, Vol. 67, Beijing Science and Technology Press, Beijing, 2005.Google Scholar
- 3.A. Rodgman and T. A. Perfetti, The Chemical Components of Tobacco and Tobacco Smoke, CRC Press, Taylor and Francis Group, Boca Raton, Florida, 2008.Google Scholar
- 19.D. Q. Yu and J. S. Yang, Handbook of Analytical Chemistry, Vol. 7, Nuclear Magnetic Resonance spectroscopy, Chemical Industry Press, 2nd Ed., Beijing, 1999.Google Scholar