Chemistry of Natural Compounds

, Volume 50, Issue 5, pp 965–967 | Cite as

Chemical Constituents of the Roots of Trichosanthes kirilowii

  • Xin Chai
  • Shan-Shan Li
  • Lin Zhu
  • Yue-Fei Wang
  • Xiu-Mei Gao

The genus Trichosanthes Linn. (Cucurbitaceae) is composed of about 50 species distributed mainly in Southeast Asia. In traditional Chinese medicine the roots of Trichosanthes kirilowii Maxim., commonly known as “Tian Hua Fen,” are used for the treatment of cough, inflammation, polydipsia, and diabetes [1]. Most previous phytochemical studies of T. kirilowii have focused on the fruits and seeds, and triterpenoids, sterols, amino acid, lipids, and other compounds have been isolated from different parts of the plant [2, 3, 4, 5].

In our research on chemical constituents of the roots of T. kirilowii, which has rarely been reported in recent years, 18 compounds were isolated and elucidated as 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid (1), allantoin (2), nicotinic acid (3), xanthine (4), adenine (5), uracil (6), thymine (7), guanosine (8), uridine (9), phenylalanine (10), tyrosine (11), 1-C-(p-hydroxyphenyl)-glycerol (12), furoic acid (13), p-hydroxybenzoic acid (14), p-hyd...


EtOAc Succinic Acid White Powder Allantoin White Needle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was financially supported by Tianjin Science and Technology Plan Project (10ZCKFSY09100), Project of New Drug Discovery Platform (2011ZX09201-201-21), and Program from National Natural Science Foundation of China (81125024).


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Xin Chai
    • 1
    • 2
  • Shan-Shan Li
    • 1
    • 2
  • Lin Zhu
    • 1
    • 2
  • Yue-Fei Wang
    • 1
    • 2
  • Xiu-Mei Gao
    • 1
    • 2
  1. 1.Tianjin State Key Laboratory of Modern Chinese MedicineTianjin University of Traditional Chinese MedicineTianjinP. R. China
  2. 2.Tianjin Key Laboratory of TCM Chemistry and AnalysisTianjin University of Traditional Chinese MedicineTianjinP. R. China

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