Chemical Constituents of the Roots of Trichosanthes kirilowii
The genus Trichosanthes Linn. (Cucurbitaceae) is composed of about 50 species distributed mainly in Southeast Asia. In traditional Chinese medicine the roots of Trichosanthes kirilowii Maxim., commonly known as “Tian Hua Fen,” are used for the treatment of cough, inflammation, polydipsia, and diabetes . Most previous phytochemical studies of T. kirilowii have focused on the fruits and seeds, and triterpenoids, sterols, amino acid, lipids, and other compounds have been isolated from different parts of the plant [2, 3, 4, 5].
In our research on chemical constituents of the roots of T. kirilowii, which has rarely been reported in recent years, 18 compounds were isolated and elucidated as 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid (1), allantoin (2), nicotinic acid (3), xanthine (4), adenine (5), uracil (6), thymine (7), guanosine (8), uridine (9), phenylalanine (10), tyrosine (11), 1-C-(p-hydroxyphenyl)-glycerol (12), furoic acid (13), p-hydroxybenzoic acid (14), p-hyd...
KeywordsEtOAc Succinic Acid White Powder Allantoin White Needle
This work was financially supported by Tianjin Science and Technology Plan Project (10ZCKFSY09100), Project of New Drug Discovery Platform (2011ZX09201-201-21), and Program from National Natural Science Foundation of China (81125024).
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