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Chemistry of Natural Compounds

, Volume 50, Issue 4, pp 669–672 | Cite as

Biotransformation of Dehydroepiandrosterone by Cell Suspension Culture of Codiaeum variegatum

  • Saifullah
  • Azizuddin
  • Saifullah Khan
  • Kashif Ali
  • Muhammad Iqbal Choudhary
Article
  • 111 Downloads

Dehydroepiandrosterone (1) was incubated with a cell suspension culture of Codiaeum variegatum for biotransformational studies. After 10 days of incubation, four metabolites, 5α-androstane-3,17-dione (2), 5β-androstane-3,17-dione (3), androst-4-ene-3,17-dione (4), and 17β-hydroxyandrost-4-en-3-one (5), were obtained. The structures of these biotransformed products were elucidated by spectroscopic methods. Biotransformation using a cell suspension culture of Codiaeum variegatum provides an effective and convenient method to oxidize the 3β-hydroxy group in 1.

Keywords

Dehydroepiandrosterone (DHEA) cell suspension culture Codiaeum variegatum biotransformation 

Notes

Acknowledgment

One of us (Azizuddin) acknowledges the enabling role of the Federal Urdu University of Arts, Science & Technology, Gulshan-e-Iqbal, Karachi, Pakistan, and appreciate its financial support through the “Mini Research Project.”

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Saifullah
    • 1
  • Azizuddin
    • 2
  • Saifullah Khan
    • 1
  • Kashif Ali
    • 1
  • Muhammad Iqbal Choudhary
    • 1
  1. 1.H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological SciencesUniversity of KarachiKarachiPakistan
  2. 2.Department of ChemistryFederal Urdu University of Arts, Science & TechnologyKarachiPakistan

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