Biotransformation of Ginsenoside Rc into C-Mc1 by the Bacterium Sphingopyxis sp. BG97
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The principal biologically active compounds of Panax ginseng C. A. Meyer are triterpenoid glycosides, ginsenosides , which exhibit immunostimulating, anti-inflammatory, anticarcinogenic, antitumor, antidiabetic, hepatoprotective, neuromodulating, and other properties . Greater than 50 different ginsenosides have been isolated from P. ginseng. Six of these (Rb1, Rb2, Rc, Rd, Re, and Rg1) make up >80% of total saponins and have protopanaxadiol or protopanaxatriol as the aglycon . Furthermore, it is well known that minor glycosides of P. ginseng in several instances have broader spectra of biological activity or are more active than them . This stimulates great interest in producing the minor ginsenosides, including biotransformation of the principal ginsenosides using various microorganisms [3, 4].
KeywordsGinsenoside BuOH Ginseng Root Biotransformation Product Human Stomach Cancer
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