Chemistry of Natural Compounds

, Volume 50, Issue 3, pp 565–567 | Cite as

Biotransformation of Ginsenoside Rc into C-Mc1 by the Bacterium Sphingopyxis sp. BG97

  • L. N. Ten
  • S. M. Chae
  • S.-A. Yoo

The principal biologically active compounds of Panax ginseng C. A. Meyer are triterpenoid glycosides, ginsenosides [1], which exhibit immunostimulating, anti-inflammatory, anticarcinogenic, antitumor, antidiabetic, hepatoprotective, neuromodulating, and other properties [2]. Greater than 50 different ginsenosides have been isolated from P. ginseng. Six of these (Rb1, Rb2, Rc, Rd, Re, and Rg1) make up >80% of total saponins and have protopanaxadiol or protopanaxatriol as the aglycon [1]. Furthermore, it is well known that minor glycosides of P. ginseng in several instances have broader spectra of biological activity or are more active than them [2]. This stimulates great interest in producing the minor ginsenosides, including biotransformation of the principal ginsenosides using various microorganisms [3, 4].

We reported earlier the transformation of ginsenoside Rb1 into the minor glycoside F-2 and compound K [ 5] and glycoside Rd into minor ginsenoside (20 S)-Rg 3 [ 6] using bacteria...


Ginsenoside BuOH Ginseng Root Biotransformation Product Human Stomach Cancer 
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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Biology and Medicinal SciencePai Chai UniversityDaejeonRepublic of Korea

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