Chemistry of Natural Compounds

, Volume 50, Issue 3, pp 557–559 | Cite as

Brominated Pimarane Diterpenoids from the sea Hare Aplysia pulmonica from the South China Sea

  • Wen-Tao Bian
  • Zhong-Jie You
  • Chang-Yun Wang
  • Chang-Lun Shao

Sea hares, which have very high medicinal value, are shell-less and slow-moving marine mollusks that feed on various algae and are known to be a rich source of bioactive secondary metabolites, mainly terpenoids, acetogenins, macrolides, and peptides. For example, a novel triazabicyclo[3.2.1]octane aplaminal showed potent cytotoxic activity against HeLa S3 [1]. Another compound, 24-membered macrolide aplyronine A, a potent antitumor substance, exhibited exceedingly potent antitumor activity in vivo against P388 murine leukemia, Lewis lung carcinoma, Ehrlich carcinoma, colon 26 carcinoma, and B16 melanoma [2]. In the course of our search for biologically natural products from marine invertebrates and their derivedfungi collected from the South China Sea, we found that the EtOAc crude extract of the sea hare Aplysia pulmonicadisplayed obvious toxic activity against brine shrimp at a concentration of 100 μg/mL. As we know, there is no related report of the secondary metabolites from this...


EtOAc CD3OD Cyclobutane Dietary Origin Ehrlich Carcinoma 
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This work was supported by the Key Program of National Natural Science Foundation of China (No. 41130858) and Program for New Century Excellent Talents in University, Ministry of Education of China (No. NCET- 11-0472).


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and PharmacyOcean University of ChinaQingdaoP. R. China
  2. 2.Faculty of Life Science & BiotechnologyNingbo UniversityNingboP. R. China

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