Chemistry of Natural Compounds

, Volume 50, Issue 1, pp 68–71 | Cite as

Lipids from the Aerial Part of Scutellaria ramosissima

  • N. K. Yuldasheva
  • N. T. Ul’chenko
  • N. Mamadalieva
  • A. I. Glushenkova
  • E. Ovidi
  • D. Triggiani
  • A. Tiezzi

Total lipids (TL) (2.1%), more than half of which were glycolipids (GL) (1.3%), and neutral lipids (NL) (0.54%) and phospholipids (PL) (0.26%) were isolated from the air-dried aerial part of Scutellaria ramosissima. The principal acids of the NL were 16:0, 18:2, and 18:3. Acid 16:0 (up to 40 mass% of the acids) dominated the glycolipids. Palmitic and linoleic acids dominated the PL with 18:1 in combination with 18:3 comprising slightly greater than 31%, like linoleic acid. The chlorophyll content was 197.3 mg% in the total lipids; carotinoids, 157.1 mg%; tocopherols, 357.0 mg% in unsaponified substances (US). The cytotoxic activity of the S. ramosissima lipid fractions was tested on HL-60 and HeLa cancer cell lines using the MTT test. PL, NL, and US showed cytotoxicity for HL-60 cells with IC50 values of 8.3, 22.0, and 24.3 μg/mL, respectively, and were inactive for HeLa cells. The GL and TL turned out to be slightly active.


Scutellaria ramosissima neutral lipids glycolipids phospholipids unsaponified substances cytotoxic activity 


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • N. K. Yuldasheva
    • 1
  • N. T. Ul’chenko
    • 1
  • N. Mamadalieva
    • 1
  • A. I. Glushenkova
    • 1
  • E. Ovidi
    • 2
  • D. Triggiani
    • 2
  • A. Tiezzi
    • 2
  1. 1.S. Yu. Yunusov Institute of the Chemistry of Plant SubstancesAcademy of Sciences of the Republic of UzbekistanTashkentUzbekistan
  2. 2.Department for Innovation in Biological, Agro-food and Forestal Systems, Laboratory of Plant Cytology and BiotechnologyTuscia University, Largo dell’UniversitaViterboItaly

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