NW-G12, a Novel Nonchlorinated Cyclohexapeptide from Streptomyces alboflavus 313
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In our continuous investigation of metabolites of Streptomyces alboflavus 313, NW-G12 (1), a novel nonchlorinated analogue of NW-G01, was obtained as a trace constituent in the weak polarity part and a known desertomycin A (2) was also isolated from the fermentation broth in the strong polarity part. The structures of compounds 1 and 2 were established by comprehensive analysis of 1D and 2D NMR spectral data. Moreover, compounds 1 and 2 showed strong antibacterial activities against Bacillus cereus, Staphylococcus aureus, and Bacillus subtilis, with MICs of less than 10 μg/mL, but both show no antibacterial activities against two gram-negative bacteria.
KeywordsNW-G12 desertomycin A antibacterial activities Streptomyces alboflavus 313
This work was financially supported by the Natural Science Foundation of China (No. 31101468) and the National Key Science and Technology Research Foundation of China (No. 2010CB126105).
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