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A new furostanol glycoside with fatty acid synthase inhibitory activity from Ophiopogon japonicusa

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Chemistry of Natural Compounds Aims and scope

A new furostanol glycoside, named ophiopogonin J (1), was isolated from the fibrous root of Ophiopogon japonicas. The structure of the compound was established as (25R)-26-[(O-β-D-glucopyranosyl-(1 → 2)-β-D-glucopyranosyl)]-20α -hydroxyfurost-5, 22-diene-3-O-α-L-rhamnopyranosyl-(1 → 2)-[β-D-xylopyranosyl(1 → 4)]-β-D-glucopyranoside on the basis of spectroscopic methods, including HR-ESI-MS and 1D and 2D NMR experiments.

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Acknowledgment

This work was supported by Special Science and Technology Projects for Outstanding Young in Life Sciences (KSCX2-EW-Q-19), the Twelfth Five Year Plan Basic Frontier Project in Life Sciences (Y129015EA2), Program for Changjiang Scholar and Innovative Team in University (No. 985-2-063-112), the President Funding of GUCAS (O95101PY00), as well as the K. C. Wong Education Foundation, Hong Kong.

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Authors and Affiliations

  1. School of Pharmaceutical Sciences, Peking University, 100191, Beijing, P. R. China

    Changling Duan, Yong Jiang & Pengfei Tu

  2. College of Life Science, Graduate University of Chinese Academy of Sciences, 100049, Beijing, P. R. China

    Yi Wang & Xiaofeng Ma

  3. Xiyuan Hospital, China Academy of Chinese Medical Sciences, 100091, Beijing, P. R. China

    Changling Duan & Jianxun Liu

Authors
  1. Changling Duan
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  2. Yi Wang
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  3. Xiaofeng Ma
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  4. Yong Jiang
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  5. Jianxun Liu
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  6. Pengfei Tu
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Corresponding authors

Correspondence to Xiaofeng Ma or Pengfei Tu.

Additional information

Materials presented at the 9th International Symposium on the Chemistry of Natural Compounds (SCNC, People' s Republic of China, Urumqi, Oct. 16–19, 2011).

Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2012, pp. 551–553.

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Duan, C., Wang, Y., Ma, X. et al. A new furostanol glycoside with fatty acid synthase inhibitory activity from Ophiopogon japonicusa . Chem Nat Compd 48, 613–615 (2012). https://doi.org/10.1007/s10600-012-0325-y

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  • DOI: https://doi.org/10.1007/s10600-012-0325-y

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