Chemistry of Natural Compounds

, Volume 48, Issue 4, pp 613–615 | Cite as

A new furostanol glycoside with fatty acid synthase inhibitory activity from Ophiopogon japonicusa

  • Changling Duan
  • Yi Wang
  • Xiaofeng Ma
  • Yong Jiang
  • Jianxun Liu
  • Pengfei Tu

A new furostanol glycoside, named ophiopogonin J (1), was isolated from the fibrous root of Ophiopogon japonicas. The structure of the compound was established as (25R)-26-[(O-β-D-glucopyranosyl-(1 → 2)-β-D-glucopyranosyl)]-20α -hydroxyfurost-5, 22-diene-3-O-α-L-rhamnopyranosyl-(1 → 2)-[β-D-xylopyranosyl(1 → 4)]-β-D-glucopyranoside on the basis of spectroscopic methods, including HR-ESI-MS and 1D and 2D NMR experiments.


Ophiopogon japonicus furostanol glycoside fatty acid synthase Liliaceae 



This work was supported by Special Science and Technology Projects for Outstanding Young in Life Sciences (KSCX2-EW-Q-19), the Twelfth Five Year Plan Basic Frontier Project in Life Sciences (Y129015EA2), Program for Changjiang Scholar and Innovative Team in University (No. 985-2-063-112), the President Funding of GUCAS (O95101PY00), as well as the K. C. Wong Education Foundation, Hong Kong.


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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  1. 1.School of Pharmaceutical SciencesPeking UniversityBeijingP. R. China
  2. 2.College of Life ScienceGraduate University of Chinese Academy of SciencesBeijingP. R. China
  3. 3.Xiyuan Hospital, China Academy of Chinese Medical SciencesBeijingP. R. China

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