A new furostanol glycoside with fatty acid synthase inhibitory activity from Ophiopogon japonicusa
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A new furostanol glycoside, named ophiopogonin J (1), was isolated from the fibrous root of Ophiopogon japonicas. The structure of the compound was established as (25R)-26-[(O-β-D-glucopyranosyl-(1 → 2)-β-D-glucopyranosyl)]-20α -hydroxyfurost-5, 22-diene-3-O-α-L-rhamnopyranosyl-(1 → 2)-[β-D-xylopyranosyl(1 → 4)]-β-D-glucopyranoside on the basis of spectroscopic methods, including HR-ESI-MS and 1D and 2D NMR experiments.
KeywordsOphiopogon japonicus furostanol glycoside fatty acid synthase Liliaceae
This work was supported by Special Science and Technology Projects for Outstanding Young in Life Sciences (KSCX2-EW-Q-19), the Twelfth Five Year Plan Basic Frontier Project in Life Sciences (Y129015EA2), Program for Changjiang Scholar and Innovative Team in University (No. 985-2-063-112), the President Funding of GUCAS (O95101PY00), as well as the K. C. Wong Education Foundation, Hong Kong.
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