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Chemistry of Natural Compounds

, Volume 48, Issue 1, pp 54–55 | Cite as

Synthesis and antineoplastic activity of novel water-soluble curcumol derivatives

  • Fang Xu
  • Quanshu Di
  • Juan Wei
  • Xianghui Li
  • Zhao Jing
  • Jianxin Lu
  • Changlin Zou
Article

6-Succinyl curcumol sodium salt was synthesized by reaction of curcumol with succinic acid. The structure of the derivative was confirmed by NMR spectroscopy and mass spectrometry. Furthermore, the derivative showed antitumor activity, which makes it a promising antitumor drug candidate that overcomes the insolubility in water.

Keywords

curcumol water-solubility NMR antitumor activity 

Notes

Acknowledgment

The work was supported financially by the Program of Traditional Chinese Medicine Foundation of Zhejiang Province, China (2008CB051), the Science Foundation of Zhejiang Province, China (Y2090579), and a grant from the Zhejiang Provincial Top Key Discipline of Laboratory Medicine.

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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • Fang Xu
    • 1
  • Quanshu Di
    • 2
  • Juan Wei
    • 2
  • Xianghui Li
    • 1
  • Zhao Jing
    • 2
  • Jianxin Lu
    • 1
  • Changlin Zou
    • 2
  1. 1.Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life ScienceWenzhou Medical CollegeWenZhouP. R. China
  2. 2.Department of Radio-Chemotherapy OncologyThe First Affiliated Hospital of Wenzhou Medical CollegeWenZhouP. R. China

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