Synthesis and antineoplastic activity of novel water-soluble curcumol derivatives
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6-Succinyl curcumol sodium salt was synthesized by reaction of curcumol with succinic acid. The structure of the derivative was confirmed by NMR spectroscopy and mass spectrometry. Furthermore, the derivative showed antitumor activity, which makes it a promising antitumor drug candidate that overcomes the insolubility in water.
Keywordscurcumol water-solubility NMR antitumor activity
The work was supported financially by the Program of Traditional Chinese Medicine Foundation of Zhejiang Province, China (2008CB051), the Science Foundation of Zhejiang Province, China (Y2090579), and a grant from the Zhejiang Provincial Top Key Discipline of Laboratory Medicine.
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