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Synthesis and antineoplastic activity of novel water-soluble curcumol derivatives

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Chemistry of Natural Compounds Aims and scope

6-Succinyl curcumol sodium salt was synthesized by reaction of curcumol with succinic acid. The structure of the derivative was confirmed by NMR spectroscopy and mass spectrometry. Furthermore, the derivative showed antitumor activity, which makes it a promising antitumor drug candidate that overcomes the insolubility in water.

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References

  1. State Pharmacopeia Commission of the People_s Republic of China. Pharmacopoeia of the People′s Republic of China [S]. 2005 ed. Part I, Beijing, Chemical Industry Press (2005), p. 195.

  2. Hai Lin and Huixiao Li, China Pharmacy, 19, 2328 (2008).

    CAS  Google Scholar 

  3. Minzhi Liu and Lichun Xu, Chin. J. Prim. Med. Pharm., 12, 938 (2005).

    Google Scholar 

  4. I. Camby, I. Salmon, A. Danguy, J. L. Pasteels, J. Brotchi, and J. Martinez, J. Natl. Cancer. Inst., 88, 594 (1996).

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgment

The work was supported financially by the Program of Traditional Chinese Medicine Foundation of Zhejiang Province, China (2008CB051), the Science Foundation of Zhejiang Province, China (Y2090579), and a grant from the Zhejiang Provincial Top Key Discipline of Laboratory Medicine.

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Authors and Affiliations

  1. Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Science, Wenzhou Medical College, WenZhou, 325035, P. R. China

    Fang Xu, Xianghui Li & Jianxin Lu

  2. Department of Radio-Chemotherapy Oncology, The First Affiliated Hospital of Wenzhou Medical College, WenZhou, 325035, P. R. China

    Quanshu Di, Juan Wei, Zhao Jing & Changlin Zou

Authors
  1. Fang Xu
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  2. Quanshu Di
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  3. Juan Wei
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  4. Xianghui Li
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  5. Zhao Jing
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  6. Jianxin Lu
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  7. Changlin Zou
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Corresponding author

Correspondence to Changlin Zou.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 1, pp. 52–53, January–February, 2012.

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Xu, F., Di, Q., Wei, J. et al. Synthesis and antineoplastic activity of novel water-soluble curcumol derivatives. Chem Nat Compd 48, 54–55 (2012). https://doi.org/10.1007/s10600-012-0157-9

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  • DOI: https://doi.org/10.1007/s10600-012-0157-9

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