Chemistry of Natural Compounds

, Volume 47, Issue 6, pp 906–910 | Cite as

Antitumor sesquiterpene polyol esters from Celastrus angulatus

  • Shao-peng Wei
  • Jie-yu Luan
  • Zhi-qin Ji
  • Bao-jun Shi
  • Min Xu
  • Ji-wen Zhang

Two new antitumor sesquiterpene polyol esters with the β-dihydroagarofuran skeleton, 1 and 2, and three known compounds 35 were isolated from the high-polar MeOH extracts of the root bark of Celastrus angulatus. Their chemical structures were elucidated mainly by analyses of MS and NMR spectral data. Preliminary antitumor and insecticidal activities of these compounds were evaluated. Compounds 1 and 2 exhibited moderate antitumor activity against human breast cancer cell line (Bcap-37); the IC50 were 54.08 and 61.35 μM, respectively, and all the tested compounds were shown to possess minimal or no inhibitory activities against human colon (HT-29) and lung (NCI-H460) cancer cell lines. In addition, compounds 15 displayed mild insecticidal activities against the 4th instar larvae Mythimna separate, the KD50 were 610.5, 308.8, 917.8, 510.6 and 1120.5, respectively.


Celastrus angulatus β-dihydroagarofuran antitumor activity insecticidal activity 



This work was supported by the National Key S & T Research Foundation of China (2010CB126105) and the National Natural Science Foundation of China (30871663, 30800729).


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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • Shao-peng Wei
    • 1
  • Jie-yu Luan
    • 2
  • Zhi-qin Ji
    • 1
  • Bao-jun Shi
    • 1
  • Min Xu
    • 2
  • Ji-wen Zhang
    • 1
  1. 1.Institute of Pesticide Science and College of Sciences Northwest Agricultural & Forestry UniversityYanglingP. R. China
  2. 2.Xi’an Modern Chemistry Research InstituteXi’anP. R. China

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