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Antitumor sesquiterpene polyol esters from Celastrus angulatus

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Chemistry of Natural Compounds Aims and scope

Two new antitumor sesquiterpene polyol esters with the β-dihydroagarofuran skeleton, 1 and 2, and three known compounds 3–5 were isolated from the high-polar MeOH extracts of the root bark of Celastrus angulatus. Their chemical structures were elucidated mainly by analyses of MS and NMR spectral data. Preliminary antitumor and insecticidal activities of these compounds were evaluated. Compounds 1 and 2 exhibited moderate antitumor activity against human breast cancer cell line (Bcap-37); the IC50 were 54.08 and 61.35 μM, respectively, and all the tested compounds were shown to possess minimal or no inhibitory activities against human colon (HT-29) and lung (NCI-H460) cancer cell lines. In addition, compounds 1–5 displayed mild insecticidal activities against the 4th instar larvae Mythimna separate, the KD50 were 610.5, 308.8, 917.8, 510.6 and 1120.5, respectively.

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References

  1. Jinming Gao, Wenjun Wu, Jiwen Zhang, and Yasuo Konishi, Nat. Prod. Rep., 24, 1153 (2007).

    Article  PubMed  CAS  Google Scholar 

  2. Weiping Yin, Tianzeng Zhao, Lingjie Gao, Dapeng Zou, Hongmin Liu, and Jianxun Kang, Phytochemistry, 52, 1731 (1999).

    Article  CAS  Google Scholar 

  3. Ming an Wang, Wenjun Wu, Jingbo Zhu, Zhiqin Ji, and Wenming Zhou, Nat. Prod. Res., 20, 653 (2006).

  4. Yongqiang Tu, Song, Qingbao Song, and Xiaoli Wu, Acta Chim. Sin., 51, 404 (1993).

  5. N. Wakbayashi, Wenjun Wu, and R. Waters, J. Nat. Prod., 51, 537 (1988).

    Article  Google Scholar 

  6. Zhiqin Ji, Zhaonong Hu, and Guoqiang Liu, Acta Bot. Boreali-Occident. Sin., 24, 748 (2004).

    CAS  Google Scholar 

  7. Wenjun Wu, Minan Wang, Jinbo Zhu, Wenming Zhou, Zhaonong Hu, and Zhiqin Ji, J. Nat. Prod., 64, 364 (2001).

    Article  PubMed  CAS  Google Scholar 

  8. Wenjun Wu, Yongqiang Tu, Huixia Liu, and Jinbo Zhu, J. Nat. Prod., 55, 1294 (1992).

    Article  CAS  Google Scholar 

  9. Shaopeng Wei, Minan Wang, Jiwen Zhang, Yong Qian, Zhiqin Ji, and Wenjun Wu, Nat. Prod. Commun., 4, 461 (2009).

    PubMed  CAS  Google Scholar 

  10. Shaopeng Wei, Zhiqin Ji, and Jiwen Zhang, Molecules, 14, 1396 (2009).

    Article  PubMed  CAS  Google Scholar 

  11. Zhiqin Ji, Wenjun Wu, Hua Yang, Baojun Shi, and Mingan Wang, Nat. Prod. Res., 21, 334 (2007).

    Article  CAS  Google Scholar 

  12. Wenjun Wu, Minan Wang, Wenming Zhou, Jingbo Zhu, Zhiqin Ji, and Zhaonong Hu, Phytochemistry, 58, 1183 (2001).

    Article  CAS  Google Scholar 

  13. Jinbo Zhu, Minan Wang, Wenjun Wu, Zhiqin Ji, and Zhaonong Hu, Phytochemistry, 61, 699 (2002).

    Article  CAS  Google Scholar 

  14. Mingjian Wu, Tianzeng Zhao, and Yujun Shang, Chin. Chem. Lett., 15, 41 (2004).

    CAS  Google Scholar 

  15. Jinyung Kim, Hanmo Koo, and Darrick S. H. L. Kim, Bioorg. Med. Chem. Lett., 11, 2405 (2001).

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgment

This work was supported by the National Key S & T Research Foundation of China (2010CB126105) and the National Natural Science Foundation of China (30871663, 30800729).

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Authors and Affiliations

  1. Institute of Pesticide Science and College of Sciences Northwest Agricultural & Forestry University, Yangling, Shaanxi, 712100, P. R. China

    Shao-peng Wei, Zhi-qin Ji, Bao-jun Shi & Ji-wen Zhang

  2. Xi’an Modern Chemistry Research Institute, Xi’an, Shaanxi, 710065, P. R. China

    Jie-yu Luan & Min Xu

Authors
  1. Shao-peng Wei
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  2. Jie-yu Luan
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  3. Zhi-qin Ji
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  4. Bao-jun Shi
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  5. Min Xu
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  6. Ji-wen Zhang
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Corresponding author

Correspondence to Ji-wen Zhang.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 6, pp. 796–799, November–December 2011.

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Wei, Sp., Luan, Jy., Ji, Zq. et al. Antitumor sesquiterpene polyol esters from Celastrus angulatus . Chem Nat Compd 47, 906–910 (2012). https://doi.org/10.1007/s10600-012-0101-z

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  • DOI: https://doi.org/10.1007/s10600-012-0101-z

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