Synthesis and calming activity of 9-(4-β-D-allopyranosyloxyphenyl)-decahydroacridine-1,8-dione derivatives
- 69 Downloads
Seven helicid derivatives containing decahydroacridine-1,8-dione were prepared via the reactions between 1,3-cyclohexanedione or 5,5-dimethyl-1,3-cyclohexanedione and the corresponding Schiff base. The structures of the helicid derivatives were characterized by IR, 1H NMR, and HR-MS spectrum. The target compounds were evaluated by their hypnotic-sedative activity in vivo. The preliminary bioassay tests showed that some of the compounds had more potent activity than that of helicid.
Keywordshelicid decahydroacridine-1,8-dione hypnotic-sedative
The authors are thankful to the Analytical & Testing Center, Sichuan University, P. R. China for providing analytical data, and to Mr. Bao (College of Pharmacy, Sichuan University) for completing the sedative-hypnotic test.
- 1.W. S. Chen, S. D. Lu, and B. Eberhard, Liebigs Ann. Chem., 10, 1893 (1981).Google Scholar
- 2.J. Z. Sha and H. K. Mao, Chin. Pharm. Bull., 22, 27 (1987).Google Scholar
- 9.D. Q. Shi, J. W. Shi, and H. Yao, Chin. J. Org. Chem., 29, 239 (2009).Google Scholar
- 10.D. Q. Shi, S. N. Ni, and G. L. Dou, Chin. J. Org. Chem., 29, 788 (2009).Google Scholar