Seven helicid derivatives containing decahydroacridine-1,8-dione were prepared via the reactions between 1,3-cyclohexanedione or 5,5-dimethyl-1,3-cyclohexanedione and the corresponding Schiff base. The structures of the helicid derivatives were characterized by IR, 1H NMR, and HR-MS spectrum. The target compounds were evaluated by their hypnotic-sedative activity in vivo. The preliminary bioassay tests showed that some of the compounds had more potent activity than that of helicid.
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Acknowledgment
The authors are thankful to the Analytical & Testing Center, Sichuan University, P. R. China for providing analytical data, and to Mr. Bao (College of Pharmacy, Sichuan University) for completing the sedative-hypnotic test.
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Published in Khimiya Prirodnykh Soedinenii, No. 4, pp. 453–455, July–August, 2011.
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Zhang, K., Yang, C.L., Lv, S.M. et al. Synthesis and calming activity of 9-(4-β-D-allopyranosyloxyphenyl)-decahydroacridine-1,8-dione derivatives. Chem Nat Compd 47, 507 (2011). https://doi.org/10.1007/s10600-011-9982-5
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DOI: https://doi.org/10.1007/s10600-011-9982-5