Chemistry of Natural Compounds

, 47:507 | Cite as

Synthesis and calming activity of 9-(4-β-D-allopyranosyloxyphenyl)-decahydroacridine-1,8-dione derivatives

  • Kuan Zhang
  • Cong Ling Yang
  • Shi Ming Lv
  • Ying Li
  • Shu Fan Yin

Seven helicid derivatives containing decahydroacridine-1,8-dione were prepared via the reactions between 1,3-cyclohexanedione or 5,5-dimethyl-1,3-cyclohexanedione and the corresponding Schiff base. The structures of the helicid derivatives were characterized by IR, 1H NMR, and HR-MS spectrum. The target compounds were evaluated by their hypnotic-sedative activity in vivo. The preliminary bioassay tests showed that some of the compounds had more potent activity than that of helicid.


helicid decahydroacridine-1,8-dione hypnotic-sedative 



The authors are thankful to the Analytical & Testing Center, Sichuan University, P. R. China for providing analytical data, and to Mr. Bao (College of Pharmacy, Sichuan University) for completing the sedative-hypnotic test.


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Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • Kuan Zhang
    • 1
  • Cong Ling Yang
    • 1
  • Shi Ming Lv
    • 1
  • Ying Li
    • 1
  • Shu Fan Yin
    • 1
  1. 1.College of ChemistrySichuan UniversityChengduP. R. China

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