Chemical constituents from the roots of Uvaria rufa

  • Santi Tip-pyang
  • Kanogporn Payakarintarungkul
  • Jirapast Sichaem
  • Preecha Phuwapraisirisan

There are approximately 150 species of plants in the genus Uvaria (Annonaceae) distributed in tropical areas. Fourteen species have been found in Thailand [1]. Uvaria rufa Blume, locally knows as “Pe-Puan-Noi”, is a climber shrub plant distributed mainly in tropical rainforest areas of Thailand. An alcoholic tincture of its roots is used ethnomedically as ecbolic [2]. Previous phytochemical studies of this plant have revealed the presence of flavonoids, tectochrysin, 7-O-methylwogonine, and 6,7-O,O-dimethylbaicalein from the bark [3] and 2,5-dihydroxy-7-methoxyflavanone from the roots [4]. (E)-3,7-Bisbenzoyloxyhept-4-en-1,2,6-triol [5] and highly oxygenated cyclohexenes (zeylenol, ellipeiosol B, and ferrudiol) [2] were also isolated from the leaves of this plant. In continuation of our phytochemical investigation of this plant, we isolated 13 compounds (1–13), one flavonoid (8), and four alkaloids (9, 11–13) were isolated from this plant for the first time. To our knowledge, this is...


MeOH CH2Cl2 EtOAc CD3OD Triol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors are grateful to the Graduate School of Chulalongkorn University for fellowships and financial support.


  1. 1.
    T. Smitinand, Thai Plant Names (Botanical Names-Vernacalar Names). Khongrit Ekavibhata, Bangkok, 1980, p. 340.Google Scholar
  2. 2.
    F. A. Tudla, A. M. Aguinaldo, K. Krohn, H. Hussain, and A. P. G. Macabeo, Biochem. Syst. Ecol., 35, 45 (2007).CrossRefGoogle Scholar
  3. 3.
    V. Lojanapiwatna, K. Promsuwansiri, B. Suwannatip, and P. Wiriyachitra, J. Sci. Soc. Thailand, 7, 83 (1981).CrossRefGoogle Scholar
  4. 4.
    K. Chantrapromma, C. Pakawatchai, B. W. Skelton, A. H. White, and S. Worapatamasri, Aust. J. Chem., 42, 2289 (1989).CrossRefGoogle Scholar
  5. 5.
    A. Chayunkiat, P. Wiriyachitra, and W. Taylor, J. Sci. Soc. Thailand, 10, 239 (1984).CrossRefGoogle Scholar
  6. 6.
    P. Tuchinda, V. Reutrakul, P. Claeson, U. Pongprayoon, T. Sematong, T. Santisuk, and W. C. Taylor, Phytochemistry, 59, 169 (2002).PubMedCrossRefGoogle Scholar
  7. 7.
    M. H. H. Nkunya, J. Nat. Prod., 48, 999 (1985).CrossRefGoogle Scholar
  8. 8.
    J. F. Stevens, M. Ivancic, M. L. Deinzer, and E. Wollenweber, J. Nat. Prod., 62, 392 (1999).PubMedCrossRefGoogle Scholar
  9. 9.
    C. H. Phoebe, P. L. Schiff, J. E. Knapp, and D. J. Slatkin, Heteocycles, 14, 1977 (1980).CrossRefGoogle Scholar
  10. 10.
    Z. Zhang, H. N. Elsohly, M. R. Jacob, D. S. Pasco, L. A. Walker, and A. M. Clark, J. Nat. Prod., 65, 856 (2002).PubMedCrossRefGoogle Scholar
  11. 11.
    M. R. Khan, M. Kihara, and A. D. Omoloso, Eupomatia Laurina. Pharm. Biol., 41, 277 (2003).CrossRefGoogle Scholar
  12. 12.
    M. You, D. B. M. Wickramaratne, G. L. Silva, H. Chai, T. E. Chagwedera, N. R. Farnsworth, G. A. Cordell, A. D. Kinghorn, and J. M. Pezzuto, J. Nat. Prod., 58, 598 (1995).PubMedCrossRefGoogle Scholar
  13. 13.
    J. A. Lopez, J. G. Laurito, A. M. Brenes, F. T. Lin, M. Sharaf, L. K. Wong, and P. L. Jr. Schiff, Phytochemistry, 29, 1899 (1990).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • Santi Tip-pyang
    • 1
  • Kanogporn Payakarintarungkul
    • 1
    • 2
  • Jirapast Sichaem
    • 1
  • Preecha Phuwapraisirisan
    • 1
  1. 1.Natural Products Research Unit, Department of Chemistry, Faculty of ScienceChulalongkorn UniversityBangkokThailand
  2. 2.Program of Biotechnology, Faculty of ScienceChulalongkorn UniversityBangkokThailand

Personalised recommendations