Mechanochemical preparation of water-soluble composites based on quercetin

  • L. N. Pribytkova
  • S. A. Gusˈkov
  • A. V. Dushkin
  • S. I. Pisareva

The solubility and antioxidant activity of the bioflavonoid quercetin was increased from its mechanochemically prepared solid composites with metal carbonates and carbohydrate compounds.


quercetin mechanical treatment arabinogalactan basic magnesium carbonate bioavailability solubility activity 


  1. 1.
    V. G. Makarov, M. N. Makarova, and A. I. Selezneva, Vopr. Pitan., 74, No. 1, 10 (2005).PubMedGoogle Scholar
  2. 2.
    V. A. Portnyagina and T. V. Pochinok, Natural and Synthetic Antioxidants in Medicine [in Russian], VINITI, Moscow, 1990.Google Scholar
  3. 3.
    L. N. Pribytkova and S. M. Adekenov, Flavonoids of the Plant Genus Artemisia [in Russian], Gylym, Almaty, 1999.Google Scholar
  4. 4.
    V. A. Tutel'yan, A. K. Baturin, and E. A. Martinchik, Vopr. Pitan., 73, No. 6, 43 (2004).Google Scholar
  5. 5.
    A. V. Dushkin, E. S. Meteleva, T. G. Tolstikova, G. A. Tolstikov, N. E. Polyakov, E. N. Medvedeva, N. A. Neverova, and V. A. Babkin, Izv. Ross. Akad. Nauk, Ser. Khim., No. 6, 1274 (2008).Google Scholar
  6. 6.
    A. V. Dushkin, T. G. Tolstikova, G. A. Tolstikov, and E. S. Meteleva, RF Pat. No. 2,337,710, “Water-Soluble Medicinal Composition and Method for Its Production”; Byull. Izobret., No. 31 (2008).Google Scholar
  7. 7.
    A. V. Dushkin and N. V. Timofeeva, RF Pat. No. 2,170,582, “Method for Production of Rapidly Soluble Tablet Form of Acetylsalicylic Acid”, Byull. Izobret., No. 20 (2001).Google Scholar
  8. 8.
    A. V. Dushkin, S. A. Gus'kov, and V. N. Bugreev, RF Pat. No. 2005106640, “Method for Production of a Powered Water-Soluble Effervescent Composite”, Byull. Izobret., No. 34 (2006).Google Scholar
  9. 9.
    A. V. Dushkin, Khim. Interesakh Ustoich. Razvit., 12, 251 (2004).Google Scholar
  10. 10.
    V. A. Babkin, L. G. Kolzunova, E. N. Medvedeva, Yu. A. Malkov, and L. A. Ostroukhova, RF Pat. No. 2,256,668, “Method for Production of Arabinogalactan”, Byull. Izobret., No. 20 (2005).Google Scholar
  11. 11.
    E. N. Medvedeva, V. A. Babkin, O. A. Makarenko, S. M. Nikolaev, V. B. Khobrakova, A. M. Shulunova, T. E. Fedorova, and L. A. Es'kova, Khim. Rastit. Syr'ya, No. 4, 17 (2004).Google Scholar
  12. 12.
    S. I. Pisareva, N. V. Yudina, Yu. V. Loskutova, V. N. Burkova, and S. G. Boev, Khim. Rastit. Syr'ya, No. 3, 45 (2008).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • L. N. Pribytkova
    • 1
  • S. A. Gusˈkov
    • 2
  • A. V. Dushkin
    • 2
  • S. I. Pisareva
    • 3
  1. 1.Siberian State Medical UniversityRoszdravRussia
  2. 2.Institute of Solid-State Chemistry and Mechanochemistry, Siberian BranchRussian Academy of SciencesNovosibirskRussia
  3. 3.Institute of Petroleum Chemistry, Siberian BranchRussian Academy of SciencesTomsk-21Russia

Personalised recommendations