Advertisement

Chemistry of Natural Compounds

, Volume 47, Issue 1, pp 73–75 | Cite as

Structure of a new steroid 24S-ergost-4-en-3,6-dione from Aconitum septentrionale

  • K. A. Eshbakova
  • B. Tashkhodzhaev
  • Zh. I. Tursunov
  • K. K. Turgunov
  • Kh. M. Bobakulov
  • N. D. Abdullaev
Article

β-Sitosterol and the new phytosteroid 24S-ergost-4-en-3,6-dione were isolated from the industrial extraction waste of the alkaloid-bearing plant Aconitum septentrionale Koelle. The structure of the isolated compound was determined by x-ray structure analysis and PMR, 13C NMR, and IR spectroscopy. The crystal structure of the steroid contains a disordered terminal 24-methyl,24-isopropyl group that occupies two positions in a 0.55:0.45 ratio.

Keywords

steroids 24S-ergost-4-en-3,6-dione absolute configuration x-ray crystal structure 

Notes

Acknowledgment

The work was financed by the Basic Research Program of KKRNT, RUz, Grant FA-F3-T045. We thank Prof. M. I. Isaev for useful discussion of the results and valuable comments.

References

  1. 1.
    M. S. Yunusov, Bashkir Khim. Zh., 4, 4, 16 (1997).Google Scholar
  2. 2.
    H. Chiao, S. W. Pelletier, H. K. Desat, W. R. Rebagai, and R. W. Caldwell, Eur. J. Pharmacol., 283, 103 (1995).PubMedCrossRefGoogle Scholar
  3. 3.
    T. F. Platonova, A. D. Kuzovkov, and P. S. Massagetov, Zh. Obshch. Khim., 28, No. 1, 258 (1958).Google Scholar
  4. 4.
    N. V. Kurinnaya, Nauch. Izv. Kaz. Med. Inst., 237 (1960).Google Scholar
  5. 5.
    R. Hegnauer, Chemotaxonomie der Pflanzen, Basel; Stuttgart, 6, 882 (1973).Google Scholar
  6. 6.
    B. A. Shukhobodskii, L. P. Markova, L. V. Kuz’mina, L. A. Bakina, V. V. Alekseev, A. A. Shchelokova, G. N. Yurashevskaya, T. I. Martinson, and S. Ya. Tyulin, in: Biology and Chemistry of Plants – Sources of Phenolic Compounds and Alkaloids [in Russian], Leningrad, 1972.Google Scholar
  7. 7.
    V. G. Minaeva, Flavonoids in Plant Ontogenesis and Their Practical Use [in Russian], Nauka, Novosibirsk, 1978.Google Scholar
  8. 8.
    G. A. Denisova, Tr. Botan. Inst. Akad. Nauk SSSR, Ser. 5, Rastit. Syre, No. 4, 113 (1956).Google Scholar
  9. 9.
    K. A. Eshbakova and H. A. Aisa, Khim. Prirod. Soedin., 774 (2009).Google Scholar
  10. 10.
    H. Itokawa, M. Akasu, and M. Fujita, Chem. Pharm. Bull., 21, 1386 (1973).Google Scholar
  11. 11.
    N. Weber, Phytochemistry, 16, 1849 (1977).CrossRefGoogle Scholar
  12. 12.
    G. M. Sheldrick, Program for Empirical Absorption Correction of Area Detector Data, University of Goettingen, Goettingen, 1996.Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • K. A. Eshbakova
    • 1
  • B. Tashkhodzhaev
    • 1
  • Zh. I. Tursunov
    • 1
  • K. K. Turgunov
    • 1
  • Kh. M. Bobakulov
    • 1
  • N. D. Abdullaev
    • 1
  1. 1.S. Yu. Yunusov Institute of the Chemistry of Plant SubstancesAcademy of Sciences of the Republic of UzbekistanTashkentUzbekistan

Personalised recommendations