Chemistry of Natural Compounds

, Volume 46, Issue 1, pp 160–162 | Cite as

Metabolites of Bacillus subtilis SKB 256, growth inhibitors of phytopathogenic fungi

  • U. R. Radzhabov
  • K. Davranov

Use of bacterial antagonists or preparations prepared from them is an effective biological method for battling phytopathogenic microorganisms. In this respect, spore-forming bacteria of the genus Bacillus are promising and widely used [1, 2, 3, 4, 5]. Several compounds with antibiotic activity were isolated from different Bacillus species and characterized [5, 6]. The metabolites of B. subtilis contain low-molecular-weight peptides [5, 6]. We showed earlier [7, 8] that B. subtilis SKB 256 is an active antagonist of Fusarium oxysporum and Pseudomonas syringiae, which is consistent with the broad spectrum of antagonistic compounds from this strain.

Our goal was to study and isolate exometabolites with antifungal activity from culture liquid (CL) of strain B. subtilis SKB 256.

The total antifungal activity of exocellular metabolites of B. subtilisSKB 256 after ultrafiltration through a membrane with pore diameter ≤20 kDa was about 50% (5–6 U/mL) of the activity of starting CL...


Antifungal Activity Culture Liquid Phytopathogenic Fungus Extracellular Metabolite Separate Compound 
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Copyright information

© Springer Science+Business Media, Inc. 2010

Authors and Affiliations

  1. 1.Mirzo Ulugbek National University of UzbekistanTashkentUzbekistan

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