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Chemistry of Natural Compounds

, Volume 45, Issue 6, pp 797–799 | Cite as

A new ten-membered lactone from Tubercularia sp. TF5, an endophytic fungus of Taxus mairei

  • Ren Xu
  • Chunhua Lu
  • Xuan Wu
  • Cheng Lin
  • Zhonghui Zheng
Article

One new ten-membered lactone (1) named (Z)-4,6,9-trihydroxy-10-nonyl-3,4,5,6,9,10-hexahydrooxecin-2-one along with 5-methoxycarbonylmellein (2) and cytochalasin D (3) were isolated from the culture of the endophytic fungus strain Tubercularia sp. TF5, originally separated from the inner bark of Taxus mairei obtained in Fujian Province, Southeast China. The structures of compounds 1–3 were elucidated by spectroscopic methods. The antimicrobial and cytotoxic activities of 1 were analyzed but it showed no significant activities.

Key words

ten-membered lactone Tubercularia sp. TF5 (Z)-4,6,9-trihydroxy-10-nonyl-3,4,5,6,9,10-hexahydrooxecin-2-one. 

Notes

Acknowledgment

This work was financially supported by the Science and Technology Project of Xiamen (3502Z20063017) and the Key Grant of Chinese Ministry of Education (No. 306010).

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Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • Ren Xu
    • 1
  • Chunhua Lu
    • 1
  • Xuan Wu
    • 1
  • Cheng Lin
    • 1
  • Zhonghui Zheng
    • 1
  1. 1.Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen Engineering Research Center of Marine Microbial Drug Discovery, Fujian Laboratory of Pharmaceutical Engineering, School of Life ScienceXiamen UniversityXiamen, FujiangChina

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