A new ten-membered lactone from Tubercularia sp. TF5, an endophytic fungus of Taxus mairei
One new ten-membered lactone (1) named (Z)-4,6,9-trihydroxy-10-nonyl-3,4,5,6,9,10-hexahydrooxecin-2-one along with 5-methoxycarbonylmellein (2) and cytochalasin D (3) were isolated from the culture of the endophytic fungus strain Tubercularia sp. TF5, originally separated from the inner bark of Taxus mairei obtained in Fujian Province, Southeast China. The structures of compounds 1–3 were elucidated by spectroscopic methods. The antimicrobial and cytotoxic activities of 1 were analyzed but it showed no significant activities.
Key wordsten-membered lactone Tubercularia sp. TF5 (Z)-4,6,9-trihydroxy-10-nonyl-3,4,5,6,9,10-hexahydrooxecin-2-one.
This work was financially supported by the Science and Technology Project of Xiamen (3502Z20063017) and the Key Grant of Chinese Ministry of Education (No. 306010).
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