Chemistry of Natural Compounds

, Volume 45, Issue 6, pp 846–848 | Cite as

Reaction of 1,3,4-thiadiazol-2,5-dithiol with N-acryloyl-substituted derivatives of several alkaloids

  • T. S. Zhivotova

Potentially bioactive 2,5-bis derivatives of 1,3,4-thiadiazole with alkaloid moieties were synthesized by reaction of 1,3,4-thiadiazol-2,5-dithiol with N-acryloyl-substituted derivatives of the alkaloids anabasine, cytisine, and D-pseudoephedrine.

Key words

1,3,4-thiadiazol-2,5-dithiol alkaloids N-alkaloid-substituted acrylamides 


  1. 1.
    B. B. Umarov, M. M. Ishankhodzhaeva, K. Sh. Khusenov, N. A. Parpiev, S. A. Talipov, and B. T. Ibragimov, Zh. Org. Khim., 35, 624 (1999).Google Scholar
  2. 2.
    L. Labanauskas, V. Kal′tsas, E. Udrenaite, V. Buchinskaite, A. Brukshtus, and I. Susvilo, in: Materials of the First International Conference “Chemistry and Biological Activity of Nitrogenous Heterocycles and Alkaloids” [in Russian], 2, Moscow, 2001, p. 181.Google Scholar
  3. 3.
    T. M. Salimov, M. A. Kukaniev, I. T. Sattorov, and D. M. Osimov, Khim.-farm. Zh., 39, 2829 (2005).Google Scholar
  4. 4.
    W. Houbin, J. Shukui, M. Shufen, and Q. Zhaohai, J. China Agr. Univ., 9, 63 (2004); Ref. Zh. Khim., 19Zh304 (2004).Google Scholar
  5. 5.
    D. Vullo, M. Franohi, E. Gallori, J. Antel, A. Scozzafava, and C. Supuran, J. Med. Chem., 47, 1272 (2004); Ref. Zh. Khim., 19O 140 (2005).CrossRefPubMedGoogle Scholar
  6. 6.
    B. A. Arbuzov and E. N. Ukhvatova, Zh. Obshch. Khim., 29, 503 (1959).Google Scholar
  7. 7.
    J. Houben and T. Weyl, Methoden der organische Chemie, Vol. 4, Halogenverbindungen, 4th Ed., G. Thieme Verlag, Stuttgart, 1960.Google Scholar
  8. 8.
    T. E. Glotova, A. S. Nakhmanovich, and T. N. Komarova, Khim. Geterotsikl. Soedin., 8, 1144 (1988).Google Scholar
  9. 9.
    A. A. Katritskii, Physicochemical Methods in Chemistry of Heterocyclic Compounds [in Russian], Khimiya, Moscow, 1966, p. 59.Google Scholar
  10. 10.
    L. J. Bellamy, Advances in Infrared Group Frequencies, Methuen, London, 1968.Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  1. 1.Institute of Organic Synthesis and Carbon Chemistry of the Republic of KazakhstanKaragandaKazakhstan

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