Components from Aconitum karakolicum roots
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The isolation and structures of 22 alkaloids from the aerial part and roots of Aconitum karakolicum Rapaics (Ranunculaceae) growing in Kirgizia (Kungei and Terskei Alatau ridges) have been reported [1, 2, 3, 4]. Pharmacological studies found that the plant alkaloids possess spasmolytic, antiarrhythmic, local anesthetic, and other activities .
We investigated the chemical composition of this plant growing in Xinjiang Autonomous Region of the PRC taht was identified at the Xinjiang Institute of Ecology and Geography, AS, XAR. Plants of the genus Aconitum are frequently used in China to treat fractures, rheumatism, and neuralgia. A. karakolicum is used in Chinese folk medicine .
Air-dried ground roots (1.08 kg) were extracted with EtOH (80%, 10 × 8 L). The first two extracts were combined. Solvent was distilled off. The resulting crystals were separated with EtOH and recrystallized from acetone:water to afford 1 (0.6 g), mp 189–190°C. Compound 1was identified as saccharose by...
KeywordsAlkaloid EtOAc HMBC Spectrum Total Alkaloid Aconitine
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