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Chemistry of Natural Compounds

, 45:641 | Cite as

New cleistanthane diterpenoids and 3,4-seco-cleistanthane diterpenoids from Croton oblongifolius

  • S. Roengsumran
  • P. Pata
  • N. Ruengraweewat
  • J. Tummatorn
  • S. Pornpakakul
  • P. Sangvanich
  • S. Puthong
  • A. Petsom
Article

Two new cleistanthane-type diterpenoids, 3-hydroxycleistantha-13(17),15-diene (1) and 3,4-seco-cleistantha4(18),13(17),15-trien-3-oic acid (2), were isolated from the stem bark of Croton oblongifolius Roxb. Epoxidation of 2 gave two epoxides 3 and 4. Their structures were established on the basis of spectroscopic data. Compound 1 showed nonspecific strong cytotoxicity against human tumor cell lines, compound 2 showed weak activity, and compounds 3 and 4 were inactive.

Key words

Croton oblongifolius cleistanthane diterpenoids cytotoxicity 

Notes

Acknowledgment

We thank the Thailand Research Fund (DBG4880013), the Thai Government (Nan), and the Graduate School and Department of Chemistry, Faculty of Science, Chulalongkorn University for financial support.

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Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • S. Roengsumran
    • 1
  • P. Pata
    • 1
  • N. Ruengraweewat
    • 1
  • J. Tummatorn
    • 1
  • S. Pornpakakul
    • 1
  • P. Sangvanich
    • 1
  • S. Puthong
    • 2
  • A. Petsom
    • 1
    • 2
  1. 1.Research Centre for Bioorganic Chemistry, Department of Chemistry, Faculty of ScienceChulalongkorn UniversityBangkokThailand
  2. 2.Institute of Biotechnology and Genetic EngineeringChulalongkorn UniversityBangkokThailand

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