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Aminomethylation of formononetin and cladrin by primary amines

  • S. P. Bondarenko
  • M. S. Frasinyuk
  • V. P. Khilya
Article

The reaction of natural isoflavones formononetin and cladrin with primary amines and formalin in the presence of a base catalyst was studied. Several novel substituted 9,10-dihydro-4H,8H-chromeno [8,7-e][1,3]oxazin-4-ones containing alkyl, benzyl, or heterylalkyl substituents in the N-9 position were synthesized.

Key words

isoflavone formononetin cladrin electrophilic substitution 9,10-dihydro-4H,8H-chromeno [8,7-e][1,3]oxazin-4-one 

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Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • S. P. Bondarenko
    • 1
  • M. S. Frasinyuk
    • 1
  • V. P. Khilya
    • 1
  1. 1.Taras Shevchenko Kiev National UniversityKievUkraine

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