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Chemistry of Natural Compounds

, Volume 45, Issue 2, pp 290–292 | Cite as

Diketopiperazine constituents of marine Bacillus subtilis

  • Xiaoling Lu
  • Yunheng Shen
  • Yuping Zhu
  • Qiangzhi Xu
  • Xiaoyu Liu
  • Kunyi Ni
  • Xin Cao
  • Weidong Zhang
  • Binghua Jiao
Article

Marine organisms, especially marine microorganisms, have been proven to be a rich source of diverse arrays of bioactive metabolites with great potential for pharmaceutical and medical applications. Marine Bacillus subtilis is a common strain species, which usually produces cyclopeptide, macrolide, indole derivatives, etc. In the course of further studies, 10 diketopiperazines: cyclo(Leu-Ile) (1) [1], cyclo(Leu-Leu) (2) [2], cyclo(Trp-Pro) (3) [3], cyclo(Leu-Pro) (4) [4,5], cyclo(Phe-Ala) (5) [6], cyclo(Phe-Tyr) (6) [2], cyclo(benzyl-Gly) (7) [7], cyclo(Val-Val) (8) [8], cyclo(Gla-Tyr) (9) [9], cyclo(Ala-Tyr) (10) [10], 1-(4-hydroxyphenyl)ethanone (11) [11], and macrolactin B (12) [12] have been isolated from the marine Bacillus subtilis. Among them, compound 7 is a new natural product. All the compounds have not been reported before from this species.

The strain 201721 has been derived from sea sediment of East Sea of China. It was isolated on F1 medium [Glucose (6 g), peptone (5 g),...

Keywords

CD3OD White Powder Ethanone Indole Derivative Diketopiperazine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

The work was supported by the Shanghai Outstanding Field Leaders Program (05XD1423) and the National Hi-tech R&D Program (2007AA091501) to Dr. B. Jiao, Dr. X. Liu (2006 AA09Z416) and Dr. Q. Xu (2006 AA 09Z425).

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Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • Xiaoling Lu
    • 1
    • 2
  • Yunheng Shen
    • 3
  • Yuping Zhu
    • 1
  • Qiangzhi Xu
    • 1
  • Xiaoyu Liu
    • 1
  • Kunyi Ni
    • 2
  • Xin Cao
    • 4
  • Weidong Zhang
    • 3
  • Binghua Jiao
    • 1
  1. 1.Department of Biochemistry and Molecular Biology, College of Basic Medical SciencesSecond Military Medical UniversityShanghaiPeople′s Republic of China
  2. 2.Department of Analytical ChemistryChina Pharmaceutical UniversityNanjingP. R. China
  3. 3.College of PharmacySecond Military Medical UniversityShanghaiP. R. China
  4. 4.Department of Medicinal ChemistryChina Pharmaceutical UniversityNanjingP. R. China

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