Diketopiperazine constituents of marine Bacillus subtilis
Marine organisms, especially marine microorganisms, have been proven to be a rich source of diverse arrays of bioactive metabolites with great potential for pharmaceutical and medical applications. Marine Bacillus subtilis is a common strain species, which usually produces cyclopeptide, macrolide, indole derivatives, etc. In the course of further studies, 10 diketopiperazines: cyclo(Leu-Ile) (1) , cyclo(Leu-Leu) (2) , cyclo(Trp-Pro) (3) , cyclo(Leu-Pro) (4) [4,5], cyclo(Phe-Ala) (5) , cyclo(Phe-Tyr) (6) , cyclo(benzyl-Gly) (7) , cyclo(Val-Val) (8) , cyclo(Gla-Tyr) (9) , cyclo(Ala-Tyr) (10) , 1-(4-hydroxyphenyl)ethanone (11) , and macrolactin B (12)  have been isolated from the marine Bacillus subtilis. Among them, compound 7 is a new natural product. All the compounds have not been reported before from this species.
KeywordsCD3OD White Powder Ethanone Indole Derivative Diketopiperazine
The work was supported by the Shanghai Outstanding Field Leaders Program (05XD1423) and the National Hi-tech R&D Program (2007AA091501) to Dr. B. Jiao, Dr. X. Liu (2006 AA09Z416) and Dr. Q. Xu (2006 AA 09Z425).
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