Chemistry of Natural Compounds

, Volume 44, Issue 5, pp 594–597 | Cite as

Five unusual natural carbohydrates from Actinosynnema pretiosum


Five unusual hexose derivatives were isolated from the carbohydrate portion of the solid-state fermentation extract of Actinosynnema pretiosum ssp. auranticum ATCC 31565, which is a producing strain of maytansinoids that are a family of 19-membered macrocyclic lactams having extraordinary cytotoxic and antineoplastic activities. Their structures were determined to be 2-deoxy-α-D-arabino-hexopyranose (1), 2-deoxy-β-D-arabino-hexopyranose (2), 3,6-anhydro-2-deoxy-α-D-arabino-hexcofuranose (3), 3,6-anhydro-2-deoxy-β-D-arabino-hexofuranose (4), and 2-(D-glycerol-1,2-dihydroxyethyl)furan (5) by NMR spectroscopic experiments.

Key words

Actinosynnema pretiosum ssp. auranticum ATCC 31565 2-deoxyglucose (2-DG) 3,6-anhydro-2-deoxyglucose 2-(D-glycerol-1,2-dihydroxyethyl)furan 



This work was partially supported by the National Science Fund for Distinguished Young Scholars to Y.-M. Shen (30325044), and the National Natural Science Foundation of China (30430020).


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Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  1. 1.Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering; Xiamen Engineering Research Center of Marine Microbial Drug Discovery; Fujian Laboratory of Pharmaceutical Engineering; School of Life ScienceXiamen UniversityXiamenP. R. China
  2. 2.Bio-X Life Science Research CenterShanghai Jiaotong UniversityShanghaiChina

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