Chemistry of Natural Compounds

, Volume 44, Issue 3, pp 301–305 | Cite as

Synthesis of dipeptide derivatives of 3,4-substituted 7-hydroxycoumarins



Coumarins modified with dipeptides were prepared by condensation of N-hydroxysuccinimide esters of 2-(3,4,8-substituted-2-oxo-2H-7-chromenyloxy)-and 2-(3,4-substituted-7-methyl-2-oxo-2H-5-chromenyloxy)acetic and-propionic acids with amino acids and dipeptides.

Key words

coumarins amino-acid derivatives dipeptides activated esters synthesis 


  1. 1.
    M. M. Garazd, Ya. L. Garazd, S. V. Shilin, and V. P. Khilya, Khim. Prir. Soedin., 338 (2002).Google Scholar
  2. 2.
    M. V. Veselovskaya, S. V. Shilin, M. M. Garazd, and V. P. Khilya, Khim. Prir. Soedin., 132 (2003).Google Scholar
  3. 3.
    S. Zafaruddin Ahmad and R. D. Desai, Proc. Indian Acad. Sci. Sect. A, 5, 277 (1937).Google Scholar
  4. 4.
    P. N. Confalone and D. L. Confalone, Tetrahedron, 39, 1265 (1983).CrossRefGoogle Scholar
  5. 5.
    A. A. Gershkovich and V. K. Kibirev, Chemical Synthesis of Peptides [in Russian], Naukova Dumka, Kiev (1992), p. 71.Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  1. 1.Taras Shevchenko Kiev National UniversityKievUkraine
  2. 2.Institute of Bioorganic and Petroleum ChemistryNational Academy of Sciences of UkraineKievUkraine

Personalised recommendations