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Chemistry of Natural Compounds

, Volume 41, Issue 6, pp 701–705 | Cite as

Synthesis and Biological Activity of S-Containing Betulin Derivatives

  • I. A. Tolmacheva
  • L. N. Shelepen'kina
  • Yu. B. Vikharev
  • L. V. Anikina
  • V. V. Grishko
  • A. G. Tolstikov
Article

Abstract

S-Containing derivatives of the natural triterpenoid betulin were synthesized. It has been found that the 30-thio- and 30-sulfinylbenzimidazole derivatives of betulin exhibit anti-inflammatory activity comparable to that of sodium diclofenac.

Key words

triterpenoids betulin sulfides sulfoxides anti-inflammatory activity 

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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • I. A. Tolmacheva
    • 1
  • L. N. Shelepen'kina
    • 1
  • Yu. B. Vikharev
    • 1
  • L. V. Anikina
    • 1
  • V. V. Grishko
    • 1
  • A. G. Tolstikov
    • 1
  1. 1.Institute of Technical Chemistry, Urals DivisionRussian Academy of SciencesPerm'Russia

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