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Chemistry of Natural Compounds

, Volume 41, Issue 5, pp 508–512 | Cite as

Modified Coumarins. 17. Synthesis and Anticoagulant Activity of 3,4-Cycloannelated Coumarin D-Glycopyranosides

  • Ya. L. Garazd
  • E. M. Kornienko
  • L. N. Maloshtan
  • M. M. Garazd
  • V. P. Khilya
Article

Abstract

3,4-Cyclocondensed coumarin O-glycopyranosides containing glucose, galactose, xylose, and arabinose were synthesized by condensation of potassium salts of hydroxycoumarins and acetobromosugars. 7-(β-D-Galactopyranosyloxy)-2,3-dihydrocyclopenta[c]chromen-4-one, 3-(β-D-xylopyranosyloxy)-7,8,9,10-tetrahydrobenzo[c]chromen-6-one, and 3-(α-D-arabinopyranosyloxy)benzo[c]chromen-6-one exhibited distinct anticoagulant activity.

Key words

coumarins O-glycosides O-glycosylation anticoagulants 

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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Ya. L. Garazd
    • 1
  • E. M. Kornienko
    • 2
  • L. N. Maloshtan
    • 2
  • M. M. Garazd
    • 3
  • V. P. Khilya
    • 1
  1. 1.Taras Shevchenko Kiev National UniversityKievUkraine
  2. 2.National Pharmaceutical UniversityKhar'kovUkraine
  3. 3.Institute of Bioorganic Chemistry and PetrochemistryNational Academy of Sciences of UkraineKievUkraine

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