Synthesis of 2-triazolylpurine Phosphonates

A series of novel compounds containing triazole and phosphonate moieties were obtained under mild conditions. Reactions of 2,6-bis-(triazolyl)purine acyclic nucleoside phosphonates, in which triazole ring at C-6 atom of purine was acting as a good leaving group, and N- or S-nucleophiles allowed to obtain the respective 2-triazolylpurine phosphonates in 62–87% yields.

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Correspondence to Irina Novosjolova.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2021, 57(1), 55–62

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Kapilinskis, Z., Novosjolova, I., Bizdēna, Ē. et al. Synthesis of 2-triazolylpurine Phosphonates. Chem Heterocycl Comp 57, 55–62 (2021). https://doi.org/10.1007/s10593-021-02867-w

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Keywords

  • 2,6-bis(triazolyl)purines
  • purine phosphonates
  • 2-triazolylpurines
  • nucleophilic aromatic substitution