Synthesis and Evaluation of Biological Activity of Homodrimane Sesquiterpenoids Bearing 1,3,4-Oxadiazole or 1,3,4-Thiadiazole Units

Synthesis of novel (+)-sclareolide-based homodrimane sesquiterpenoids bearing 1,3,4-oxadiazole or 1,3,4-thiadiazole units has been reported. These terpeno-heterocyclic compounds demonstrate promising antifungal and antibacterial activities toward fungal species Aspergillus niger, Fusarium solani, Penicillium chrysogenum, Penicillium frequentans, and Alternaria alternata and bacteria strains Pseudomonas aeruginosa and Bacillus sp. with minimum inhibitory concentration at μg/ml level.

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Correspondence to Sergiu Shova or Iacob Gutu or Nicoleta Vornicu or Ionel Mangalagiu or Michele D’Ambrosio or Aculina Aricu.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2020, 56(5), 578–585

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Lungu, L., Ciocarlan, A., Smigon, C. et al. Synthesis and Evaluation of Biological Activity of Homodrimane Sesquiterpenoids Bearing 1,3,4-Oxadiazole or 1,3,4-Thiadiazole Units. Chem Heterocycl Comp 56, 578–585 (2020). https://doi.org/10.1007/s10593-020-02703-7

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Keywords

  • homodrimane sesquiterpenoid
  • oxadiazole
  • thiadiazole
  • antibacterial activity
  • antifungal activity