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N-Boc-4-aminopyrazole-5-carbaldehydes in Friendländer synthesis of pyrazolo[4,3-b]pyridines

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Chemistry of Heterocyclic Compounds Aims and scope

N-Boc-4-aminopyrazole-5-carbaldehydes reacted with aryl, hetaryl, alkyl, and cycloalkyl ketones containing methylene groups. The reactions were accomplished in refluxing acetic acid in the presence of pyrrolidine and resulted in the formation of 5-substituted and carbo[b]fused pyrazolo[4,3-b]pyridines.

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Authors and Affiliations

  1. National University “Kyiv-Mohyla Academy”, 2 Hrygorija Skovorody St., Kyiv, 04655, Ukraine

    Georgiy G. Yakovenko

  2. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv, 02094, Ukraine

    Georgiy G. Yakovenko, Oleh A. Lukianov, Andriy V. Bol’but & Mykhailo V. Vovk

  3. Enamine Ltd., 78 Chervonotkatska St., Kyiv, 02094, Ukraine

    Andriy V. Bol’but

Authors
  1. Georgiy G. Yakovenko
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  2. Oleh A. Lukianov
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  3. Andriy V. Bol’but
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  4. Mykhailo V. Vovk
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Correspondence to Georgiy G. Yakovenko.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2019, 55(4/5), 379–385

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Yakovenko, G.G., Lukianov, O.A., Bol’but, A.V. et al. N-Boc-4-aminopyrazole-5-carbaldehydes in Friendländer synthesis of pyrazolo[4,3-b]pyridines. Chem Heterocycl Comp 55, 379–385 (2019). https://doi.org/10.1007/s10593-019-02468-8

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  • DOI: https://doi.org/10.1007/s10593-019-02468-8

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