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Study of regioselectivity in cyanomethylation of 4-(trifluoromethyl)pyrimidin-2(1Н)-ones

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Chemistry of Heterocyclic Compounds Aims and scope

Cyanoacetic acid reacted selectively with 4-(trifluoromethyl)pyrimidin-2(1Н)-ones with the formation of Michael addition–decarboxylation products in DMSO solution at 85°С and Mannich reaction products when the reagents were fused together under solventfree conditions.

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Authors and Affiliations

  1. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St, Kyiv, 02094, Ukraine

    Viktor M. Tkachuk, Serhii V. Melnykov, Anastasiia V. Vorobei & Mykhailo V. Vovk

  2. LE STUDIUM Loire Valley Institute for Advanced Studies, 1 Dupanloup St, 45000, Orléans, France

    Volodymyr A. Sukach

  3. Institute of Organic and Analytical Chemistry, University of Orléans, ICOA UMR CNRS, 7311, Orléans, France

    Volodymyr A. Sukach

Authors
  1. Viktor M. Tkachuk
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  2. Serhii V. Melnykov
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  3. Anastasiia V. Vorobei
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  4. Volodymyr A. Sukach
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  5. Mykhailo V. Vovk
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Correspondence to Viktor M. Tkachuk.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2019, 55(1), 66–71

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Tkachuk, V.M., Melnykov, S.V., Vorobei, A.V. et al. Study of regioselectivity in cyanomethylation of 4-(trifluoromethyl)pyrimidin-2(1Н)-ones. Chem Heterocycl Comp 55, 66–71 (2019). https://doi.org/10.1007/s10593-019-02420-w

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  • DOI: https://doi.org/10.1007/s10593-019-02420-w

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