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Synthesis and biological activity of 3,5-diacetyl-2,6-dimethylpyridine derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

Aldol-crotonic condensation reactions of 3,5-diacetyl-2,6-dimethylpyridine with various aldehydes were used to synthesize bisazachalcone derivatives, which were subsequently cyclized with hydrazine hydrate in acetic acid, leading to the respective bisderivatives of 4,5-dihydro-1H-pyrazole. The reactions of 3,5-diacetyl-2,6-dimethylpyridine with some hydrazides also provided the respective bishydrazones. The analgesic activity of the obtained derivatives was tested.

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This work was performed with financial support from the Committee for Sciences, Ministry of Education and Science, Republic of Kazakhstan (grant No. AP05131602).

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Authors and Affiliations

  1. F. M. Dostoevskii Omsk State University, 55a Mira Ave., Omsk, 644077, Russia

    Alena L. Oleshchuk & Anastasiya A. Karbainova

  2. Republican State Enterprise “National Center for Biotechnology” under the Science Committee of Ministry of Education and Science of the Republic of Kazakhstan, 13/5 Kurgalzhinskoye Road, Astana, Kazakhstan, 010000

    Tatyana N. Krivoruchko, Zarina T. Shulgau & Ivan V. Kulakov

  3. Surgut State University, 1 Lenina Ave., Surgut, 628412, Russia

    Zarina T. Shulgau

  4. Kokshetau State University named after Sh. Ualikhanov, 76 Abay St., Kokshetau, Kazakhstan, 020000

    Tulegen M. Seilkhanov

  5. Institute of Chemistry, Tyumen State University, 15a Perekopskaya St., Tyumen, 625003, Russia

    Ivan V. Kulakov

Authors
  1. Alena L. Oleshchuk
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  2. Anastasiya A. Karbainova
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  3. Tatyana N. Krivoruchko
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  4. Zarina T. Shulgau
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  5. Tulegen M. Seilkhanov
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  6. Ivan V. Kulakov
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Correspondence to Ivan V. Kulakov.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2019, 55(1), 47–51

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Oleshchuk, A.L., Karbainova, A.A., Krivoruchko, T.N. et al. Synthesis and biological activity of 3,5-diacetyl-2,6-dimethylpyridine derivatives. Chem Heterocycl Comp 55, 47–51 (2019). https://doi.org/10.1007/s10593-019-02417-5

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  • DOI: https://doi.org/10.1007/s10593-019-02417-5

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