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An efficient method for the synthesis of 2-thiazoleacetic acid N-sulfonyl amidines

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Chemistry of Heterocyclic Compounds Aims and scope

A three-step method was designed and developed on the basis of retrosynthetic analysis for the synthesis of hybrid molecules containing a thiazole ring and an N-sulfonyl amidine fragment, connected by a methylene linker. The mechanism of the last step involves the formation of intermediate 1,2,3,4-thiatriazoles and their transformation into the final products as a result of the elimination of molecular nitrogen and sulfur.

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This work was supported by the Russian Foundation for Basic Research (grant No. 17-03-00641 / 17).

X-ray diffraction study was carried out on the equipment of the Center for Spectroscopy and Analysis of Organic compounds of the Postovsky Institute of Organic Synthesis of Ural Branch of the Russian Academy of Sciences.

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Authors and Affiliations

  1. Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg, 620002, Russia

    Vladimir G. Il’kin, Vera S. Berseneva, Pavel А. Slepukhin & Vasiliy А. Bakulev

  2. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg, 620990, Russia

    Pavel А. Slepukhin

Authors
  1. Vladimir G. Il’kin
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  2. Vera S. Berseneva
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  3. Pavel А. Slepukhin
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  4. Vasiliy А. Bakulev
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Correspondence to Vasiliy А. Bakulev.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(12), 1153–1160

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Il’kin, V.G., Berseneva, V.S., Slepukhin, P.А. et al. An efficient method for the synthesis of 2-thiazoleacetic acid N-sulfonyl amidines. Chem Heterocycl Comp 54, 1153–1160 (2018). https://doi.org/10.1007/s10593-019-02407-7

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  • DOI: https://doi.org/10.1007/s10593-019-02407-7

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