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Facile one-pot synthesis of N-fused 1,2,4-triazoles via oxidative cyclization using manganese dioxide

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Chemistry of Heterocyclic Compounds Aims and scope

A facile one-pot synthesis of N-fused 1,2,4-triazoles from heterocyclic hydrazines and aldehydes is reported. The reaction is efficiently promoted by manganese dioxide to afford the desired products mostly in high yields and in relatively short times. The mild nature of the synthesis, cheap oxidizing agent, and short reaction time are notable advantages of the developed protocol. This protocol is effective toward various substrates having different functionalities.

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Authors and Affiliations

  1. Department of Chemistry, Mewar University, Chittorgarh, Rajasthan, 312901, India

    Ashish Bhatt & Ravi Kant

  2. Department of Pharmacy, Mewar University, Chittorgarh, Rajasthan, 312901, India

    Rajesh K. Singh

Authors
  1. Ashish Bhatt
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  2. Rajesh K. Singh
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  3. Ravi Kant
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Correspondence to Ashish Bhatt.

Additional information

Supplementary information file containing 1H and 13C NMR spectra of all synthesized compounds is available at the journal website at http://link.springer.com/journal/10593.

Published in Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(12), 1111–1116

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Bhatt, A., Singh, R.K. & Kant, R. Facile one-pot synthesis of N-fused 1,2,4-triazoles via oxidative cyclization using manganese dioxide. Chem Heterocycl Comp 54, 1111–1116 (2018). https://doi.org/10.1007/s10593-019-02400-0

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  • DOI: https://doi.org/10.1007/s10593-019-02400-0

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